Global Patent Index - EP 1196162 A4

EP 1196162 A4 2003-06-18 - PROCYANIDIN OLIGOMERS FOR INHIBITING MATRIX METALLOPROTEINASES AND MEDICINE HAVING EFFECTIVE COMPOSITION OF SAME

Title (en)

PROCYANIDIN OLIGOMERS FOR INHIBITING MATRIX METALLOPROTEINASES AND MEDICINE HAVING EFFECTIVE COMPOSITION OF SAME

Title (de)

PROCYANIDIN-OLIGOMERE ALS HEMMUNG VON MATRIXMETALLOPROTEINASEN UND DIESE ALS EFFEKTIVE KOMPOSITIONEN ENTHANTENDE ARZNEIMITTEL

Title (fr)

OLIGOMERES DE PROCYANIDINES INHIBITEURS DES METALLOPROTEASES MATRICES ET MEDICAMENT LES UTILISANT COMME PRINCIPE ACTIF

Publication

EP 1196162 A4 (EN)

Application

EP 00942520 A

Priority

  • KR 0000769 W
  • KR 19990028877 A

Abstract (en)

[origin: WO0105397A1] The present invention provides procyanidin oligomers with significant biological activity against matrix metalloproteinase (MMP). The procyanidin oligomers can be isolated from the genus Ulmus and other plants and comprise trimeric through dodecameric procyanidin oligomers of flavan-3-ol monomer units. The present invention encompasses methods of using the procyanidin oligomer in treating tumor metastasis or invasion, rheumatoid arthritis, diabetes, corneal, epidermal, and gastric ulceration, skin wrinkling, periodontitis, osteoporosis; and in the promotion of wound and burn healing and other related maladies in which uncontrolled high levels of MMP are thought to play an important role in the malady progress.

IPC 1-7 (main, further and additional classification)

A61K 31/35; A61K 35/78

IPC 8 full level (invention and additional information)

C07D 311/62 (2006.01); A61K 9/06 (2006.01); A61K 9/08 (2006.01); A61K 9/10 (2006.01); A61K 9/14 (2006.01); A61K 9/16 (2006.01); A61K 9/20 (2006.01); A61K 9/48 (2006.01); A61K 9/70 (2006.01); A61K 31/35 (2006.01); A61K 31/353 (2006.01); A61K 36/00 (2006.01); A61K 36/18 (2006.01); A61K 36/185 (2006.01); A61P 1/02 (2006.01); A61P 1/04 (2006.01); A61P 3/10 (2006.01); A61P 17/02 (2006.01); A61P 17/10 (2006.01); A61P 17/16 (2006.01); A61P 19/02 (2006.01); A61P 19/10 (2006.01); A61P 27/02 (2006.01); A61P 29/00 (2006.01); A61P 35/04 (2006.01); A61P 43/00 (2006.01)

CPC (invention and additional information)

A61K 31/353 (2013.01); A61K 36/185 (2013.01)

Citation (search report)

  • [X] EP 0815857 A1 19980107 - SUNTORY LTD [JP]
  • [X] WO 9324106 A1 19931209 - OREAL [FR], et al
  • [X] FR 2770228 A1 19990430 - GREENTECH SA [FR]
  • [XY] FR 2672800 A1 19920821 - DOLISOS LAB [FR]
  • [XY] JUN CHANG-DUK ET AL: "Inhibition of nitric oxide synthesis by butanol fraction of the methanol extract of Ulmus davidiana in murine macophages.", JOURNAL OF ETHNOPHARMACOLOGY, vol. 62, no. 2, 1998, pages 129 - 135, XP002235804, ISSN: 0378-8741
  • [X] DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1995, LEE EUN BANG ET AL: "The influence of methanol extract of Ulmus davidiana var. Japonica cortex on gastric erosion and ulcer and paw edema in rats.", XP002235805, Database accession no. PREV199698732403 & YAKHAK HOEJI, vol. 39, no. 6, 1995, pages 671 - 675, ISSN: 0513-4234
  • [X] DATABASE EMBASE [online] ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL; 1994, EUN J S ET AL: "The combined effects of n-BuOH fraction of Ulmi Cortex and anticancer drugs on cancer cell lines", XP002235806, Database accession no. EMB-1994193448 & KOREAN JOURNAL OF PHARMACOGNOSY 1994 SOUTH KOREA, vol. 25, no. 2, 1994, pages 144 - 152, ISSN: 0253-3073
  • [X] GALI H V ET AL: "COMPARISON OF THE INHBITORY EFFECTS OF MONOMERIC, DIMERIC, AND TRIMERIC PROCYANIDINS ON THE BIOCHEMICAL MARKERS OF SKIN TUMOR PROMOTION IN MOUSE EPIDERMIS IN VIVO", PLANTA MEDICA, THIEME, STUTTGART, DE, vol. 60, no. 3, June 1994 (1994-06-01), pages 235 - 239, XP001088243, ISSN: 0032-0943
  • [X] MAFFEI FACINO R ET AL: "Free radicals scavenging action and anti-enzyme activities of procyanidine from Vitis vinifera: A mechanism for their capillary protective action.", ARZNEIMITTEL-FORSCHUNG, vol. 44, no. 5, 1994, pages 592 - 601, XP001146733, ISSN: 0004-4172
  • See also references of WO 0105397A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family

WO 0105397 A1 20010125; WO 0105397 A8 20010405; AU 5713000 A 20010205; BR 0012431 A 20020924; CA 2379489 A1 20010125; CN 1364082 A 20020814; EP 1196162 A1 20020417; EP 1196162 A4 20030618; JP 2003504402 A 20030204; KR 100509119 B1 20050818; KR 20010010154 A 20010205; MX PA02000598 A 20030721