EP 1196191 A1 20020417 - DEATH DOMAIN CONTAINING RECEPTOR 5
Title (en)
DEATH DOMAIN CONTAINING RECEPTOR 5
Title (de)
DEATH DOMAIN ENTHALTENDEN REZEPTOR 5
Title (fr)
RECEPTEUR 5 CONTENANT LE DOMAINE DE L'APOPTOSE
Publication
Application
Priority
- US 0012041 W 20000504
- US 13249899 P 19990504
- US 13323899 P 19990507
- US 14893999 P 19990813
Abstract (en)
[origin: WO0066156A1] The present invention relates to novel Death Domain Containing Receptor-5 (DR5) proteins which are members of the tumor necrosis factor (TNF) receptor family, and have now been shown to bind TRAIL. In particular, isolated nucleic acid molecules are provided encoding the human DR5 proteins. DR5 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of DR5 acitivity.
IPC 1-7
A61K 39/00; A61K 39/395; A61K 45/00; A01N 37/18; C07K 14/52; C07K 14/525; C07K 16/28; C07K 14/715; A61K 38/17
IPC 8 full level
G01N 33/50 (2006.01); A61K 38/00 (2006.01); A61K 39/395 (2006.01); A61K 45/00 (2006.01); A61P 29/00 (2006.01); A61P 31/12 (2006.01); A61P 35/00 (2006.01); A61P 37/02 (2006.01); A61P 37/04 (2006.01); A61P 43/00 (2006.01); C07K 14/705 (2006.01); C07K 17/08 (2006.01); C07K 19/00 (2006.01); C12N 15/09 (2006.01); C12P 21/02 (2006.01); G01N 33/15 (2006.01); G01N 33/53 (2006.01); G01N 33/566 (2006.01); G01N 33/577 (2006.01)
CPC (source: EP)
A61K 39/395 (2013.01); A61P 29/00 (2017.12); A61P 31/12 (2017.12); A61P 35/00 (2017.12); A61P 37/02 (2017.12); A61P 37/04 (2017.12); A61P 43/00 (2017.12); C07K 14/70578 (2013.01); A61K 38/00 (2013.01); C07K 2319/00 (2013.01); C07K 2319/30 (2013.01)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0066156 A1 20001109; WO 0066156 A8 20010726; AU 4817200 A 20001117; CA 2369371 A1 20001109; EP 1196191 A1 20020417; EP 1196191 A4 20040324; JP 2002543151 A 20021217
DOCDB simple family (application)
US 0012041 W 20000504; AU 4817200 A 20000504; CA 2369371 A 20000504; EP 00930329 A 20000504; JP 2000615040 A 20000504