Global Patent Index - EP 1196191 A4

EP 1196191 A4 20040324 - DEATH DOMAIN CONTAINING RECEPTOR 5

Title (en)

DEATH DOMAIN CONTAINING RECEPTOR 5

Title (de)

DEATH DOMAIN ENTHALTENDEN REZEPTOR 5

Title (fr)

RECEPTEUR 5 CONTENANT LE DOMAINE DE L'APOPTOSE

Publication

EP 1196191 A4 20040324 (EN)

Application

EP 00930329 A 20000504

Priority

  • US 0012041 W 20000504
  • US 13249899 P 19990504
  • US 13323899 P 19990507
  • US 14893999 P 19990813

Abstract (en)

[origin: WO0066156A1] The present invention relates to novel Death Domain Containing Receptor-5 (DR5) proteins which are members of the tumor necrosis factor (TNF) receptor family, and have now been shown to bind TRAIL. In particular, isolated nucleic acid molecules are provided encoding the human DR5 proteins. DR5 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of DR5 acitivity.

IPC 1-7

A61K 39/00; A61K 39/395; A61K 45/00; A01N 37/18; C07K 14/52; C07K 14/525; C07K 16/28; C07K 14/715; A61K 38/17

IPC 8 full level

A61K 38/00 (2006.01); A61K 39/395 (2006.01); A61K 45/00 (2006.01); A61P 29/00 (2006.01); A61P 31/12 (2006.01); A61P 35/00 (2006.01); A61P 37/02 (2006.01); A61P 37/04 (2006.01); A61P 43/00 (2006.01); C07K 14/705 (2006.01); C07K 17/08 (2006.01); C07K 19/00 (2006.01); C12N 15/09 (2006.01); C12P 21/02 (2006.01); G01N 33/15 (2006.01); G01N 33/50 (2006.01); G01N 33/53 (2006.01); G01N 33/566 (2006.01); G01N 33/577 (2006.01)

CPC (source: EP)

A61K 39/395 (2013.01); A61P 29/00 (2017.12); A61P 31/12 (2017.12); A61P 35/00 (2017.12); A61P 37/02 (2017.12); A61P 37/04 (2017.12); A61P 43/00 (2017.12); C07K 14/70578 (2013.01); A61K 38/00 (2013.01); C07K 2319/00 (2013.01); C07K 2319/30 (2013.01)

Citation (search report)

  • [XY] WO 9841629 A2 19980924 - HUMAN GENOME SCIENCES INC [US], et al
  • [A] EP 0870827 A2 19981014 - SMITHKLINE BEECHAM CORP [US]
  • [E] EP 1181319 A1 20020227 - GENENTECH INC [US]
  • [E] EP 1192185 A2 20020403 - GENENTECH INC [US]
  • [E] EP 1287035 A1 20030305 - UAB RESEARCH FOUNDATION [US]
  • [Y] LINDNER HEIDRUN ET AL: "Peripheral blood mononuclear cells induce programmed cell death in human endothelial cells and may prevent repair: Role of cytokines", BLOOD, vol. 89, no. 6, 1997, pages 1931 - 1938, XP002267561, ISSN: 0006-4971
  • [Y] HORIGOME ATSUSHI ET AL: "Tacrolimus-induced apoptosis and its prevention by interleukins in mitogen-activated human peripheral-blood mononuclear cells", IMMUNOPHARMACOLOGY, vol. 39, no. 1, March 1998 (1998-03-01), pages 21 - 30, XP002267562, ISSN: 0162-3109
  • [Y] CLERICI MARIO ET AL: "Type 1 and type 2 cytokines in HIV infection - A possible role in apoptosis and disease progression", ANNALS OF MEDICINE, vol. 29, no. 3, 1997, pages 185 - 188, XP009024281, ISSN: 0785-3890
  • [A] SIMONITSCH I ET AL: "Autocrine self-elimination of cultured ovarian cancer cells by tumour necrosis factor alpha (TNF-alpha)", BRITISH JOURNAL OF CANCER, vol. 78, no. 7, October 1998 (1998-10-01), pages 862 - 870, XP009024301, ISSN: 0007-0920
  • [A] ODAKA C ET AL: "Immunosuppressant deoxyspergualin induces apoptotic cell death in dividing cells", IMMUNOLOGY, vol. 95, no. 3, November 1998 (1998-11-01), pages 370 - 376, XP009024297, ISSN: 0019-2805
  • [A] HILL MARK E ET AL: "Prognostic significance of BCL-2 expression and bcl-2 major breakpoint region rearrangement in diffuse large cell non-Hodgkin's lymphoma: A British national lymphoma investigation study", BLOOD, vol. 88, no. 3, 1996, pages 1046 - 1051, XP002267563, ISSN: 0006-4971
  • [A] GOOCH JENNIFER L ET AL: "Interleukin 4 inhibits growth and induces apoptosis in human breast cancer cells", CANCER RESEARCH, vol. 58, no. 18, 15 September 1998 (1998-09-15), pages 4199 - 4205, XP001157169, ISSN: 0008-5472
  • [A] LOTEM JOSEPH ET AL: "Hematopoietic cytokines inhibit apoptosis induced by transforming growth factor-beta-1 and cancer chemotherapy compounds in myeloid leukemic cells", BLOOD, vol. 80, no. 7, 1992, pages 1750 - 1757, XP001157168, ISSN: 0006-4971
  • [A] LOTEM J ET AL: "Interferon-gamma inhibits apoptosis induced by wild-type p53, cytotoxic anti-cancer agents and viability factor deprivation in myeloid cells", LEUKEMIA (BASINGSTOKE), vol. 9, no. 4, 1995, pages 685 - 692, XP009024280, ISSN: 0887-6924
  • [A] FRANKFURT OSKAR S ET AL: "Protection from apoptotic cell death by interleukin-4 is increased in previously treated chronic lymphocytic leukemia patients", LEUKEMIA RESEARCH, vol. 21, no. 1, 1997, pages 9 - 16, XP001157166, ISSN: 0145-2126
  • [A] ZOU WEIPING ET AL: "Administration of interleukin 13 to simian immunodeficiency virus-infected macaques: Induction of intestinal epithelial atrophy", AIDS RESEARCH AND HUMAN RETROVIRUSES, vol. 14, no. 9, 10 June 1998 (1998-06-10), pages 775 - 783, XP009024312, ISSN: 0889-2229
  • See references of WO 0066156A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 0066156 A1 20001109; WO 0066156 A8 20010726; AU 4817200 A 20001117; CA 2369371 A1 20001109; EP 1196191 A1 20020417; EP 1196191 A4 20040324; JP 2002543151 A 20021217

DOCDB simple family (application)

US 0012041 W 20000504; AU 4817200 A 20000504; CA 2369371 A 20000504; EP 00930329 A 20000504; JP 2000615040 A 20000504