EP 1196199 A2 20020417 - WATER SOLUBLE MULTI-BIOTIN-CONTAINING COMPOUNDS
Title (en)
WATER SOLUBLE MULTI-BIOTIN-CONTAINING COMPOUNDS
Title (de)
WASSERLöSLICHE MULTI-BIOTIN-VERBINDUNGEN
Title (fr)
COMPOSES HYDROSOLUBLES MULTI-BIOTINE
Publication
Application
Priority
- US 0015081 W 20000601
- US 32426799 A 19990602
Abstract (en)
[origin: WO0072802A2] Water soluble discrete multi-biotin-containing compounds with at least three (3) biotin moieties are disclosed. The water soluble biotin-containing compounds may additionally comprise one or more moieties that confer resistance to cleavage by biotinidase or that is cleavable <i>in vitro</i> or <i>in vivo</i>. The discrete multi-biotin-containing compounds may include a reactive moiety that provides a site for reaction with yet another moiety, such as a targeting, diagnostic or therapeutic functional moiety. Biotinylation reagents comprising water soluble linker moieties are also disclosed and may additionally comprise a biotinidase protective group. Methods for amplifying the number of sites for binding biotin-binding proteins at a selected target using multi-biotin compounds are also disclosed.
IPC 1-7
IPC 8 full level
C07D 495/04 (2006.01); C07D 519/00 (2006.01)
CPC (source: EP)
C07D 495/04 (2013.01); Y02P 20/55 (2015.11)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0072802 A2 20001207; WO 0072802 A3 20020207; WO 0072802 A8 20010419; AU 5312100 A 20001218; EP 1196199 A2 20020417; EP 1196199 A4 20020619
DOCDB simple family (application)
US 0015081 W 20000601; AU 5312100 A 20000601; EP 00938025 A 20000601