EP 1196401 A1 20020417 - METHOD FOR PRODUCING 2-AMINOMETHYL-4-CYANO-THIAZOL
Title (en)
METHOD FOR PRODUCING 2-AMINOMETHYL-4-CYANO-THIAZOL
Title (de)
VERFAHREN ZUR HERSTELLUNG VON 2-AMINOMETHYL-4-CYANO-THIAZOL
Title (fr)
PROCEDE DE PRODUCTION DE 2-AMINOMETHYL-4-CYANO-THIAZOL
Publication
Application
Priority
- DE 19933861 A 19990723
- EP 0006562 W 20000711
Abstract (en)
[origin: US6642388B1] The invention relates to processes for preparing 2-aminomethyl-4-cyanothiazole and its salts of the formulae Ia and Ibin whichn=1 or 2 and,for n=1, X is chloride, bromide, triflate and hydrogen sulfate andfor n=2, X is sulfate, comprising the process step where the thioamide of the formula IVis stirred with a bromopyruvate of the formula V,in which R<1 >is branched or linear C1-4-alkyl in an alcohol R<2>OH in which R<2 >is branched or linear C1-8-alkyl, HO-CH2-CH2-, HO-CH2-CH2-CH2- or C1-4-alkyl- O-CH2-CH2- at from -5° C. to 40° C. until the conversion of the thioamide IV has essentially gone to completion, and to the compounds of the formulae Ia and Ib.
IPC 1-7
IPC 8 full level
C07D 277/56 (2006.01); C07K 5/065 (2006.01); C07D 277/20 (2006.01)
CPC (source: EP US)
C07D 277/56 (2013.01 - EP US); C07K 5/06078 (2013.01 - EP US)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
US 6642388 B1 20031104; AU 6157900 A 20010213; BG 106333 A 20020830; BR 0012651 A 20020409; CA 2380084 A1 20010201; CA 2380084 C 20070109; CN 1364163 A 20020814; DE 19933861 A1 20010125; EP 1196401 A1 20020417; HK 1048470 A1 20030404; HU P0202109 A2 20020928; IL 147769 A0 20020814; JP 2003505454 A 20030212; JP 2006219498 A 20060824; JP 4027092 B2 20071226; KR 20020022781 A 20020327; MX PA02000716 A 20020722; NO 20020327 D0 20020122; NO 20020327 L 20020321; PL 355110 A1 20040405; SK 1052002 A3 20020702; TR 200200183 T2 20020821; WO 0107425 A1 20010201
DOCDB simple family (application)
US 3170002 A 20020510; AU 6157900 A 20000711; BG 10633302 A 20020121; BR 0012651 A 20000711; CA 2380084 A 20000711; CN 00810618 A 20000711; DE 19933861 A 19990723; EP 0006562 W 20000711; EP 00947968 A 20000711; HK 03100004 A 20030102; HU P0202109 A 20000711; IL 14776900 A 20000711; JP 2001512510 A 20000711; JP 2006129116 A 20060508; KR 20027000959 A 20020123; MX PA02000716 A 20000711; NO 20020327 A 20020122; PL 35511000 A 20000711; SK 1052002 A 20000711; TR 200200183 T 20000711