EP 1196445 A1 20020417 - INSULIN CRYSTALS FOR PULMONARY ADMINISTRATION
Title (en)
INSULIN CRYSTALS FOR PULMONARY ADMINISTRATION
Title (de)
INSULINKRISTALLE ZUR VERABREICHUNG ÜBER DIE LUNGE
Title (fr)
CRISTAUX D'INSULINE ADMINISTRES PAR VOIE PULMONAIRE
Publication
Application
Priority
- US 0015026 W 20000612
- US 14143099 P 19990629
Abstract (en)
[origin: WO0100674A1] The invention relates to crystals comprising insulin, an insulin analog, derivatives of insulin or derivatives of an insulin analog, and a divalent metal cation, to processes for preparing such crystals, and to methods of treating diabetes or hyperglycemia comprising administering the crystals via the pulmonary route to a patient in need thereof to control blood glucose. Crystals having a volume mean spherical equivalent diameter of 1 to 5 microns are obtained. The crystal size may be controlled so that the crystals may be administered advantageously by inhalation through the mouth, deposited in the deep lung, and absorbed there over a protracted period of time, to provide control of blood glucose primarily between meals and overnight.
IPC 1-7
IPC 8 full level
A61K 38/28 (2006.01)
CPC (source: EP)
A61K 9/0073 (2013.01); A61K 38/28 (2013.01)
Citation (search report)
See references of WO 0100674A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0100674 A1 20010104; AU 5453300 A 20010131; EP 1196445 A1 20020417
DOCDB simple family (application)
US 0015026 W 20000612; AU 5453300 A 20000612; EP 00939449 A 20000612