EP 1196552 A2 20020417 - METHODS AND COMPOSITIONS FOR ENGINEERING OF ATTENUATED VACCINES
Title (en)
METHODS AND COMPOSITIONS FOR ENGINEERING OF ATTENUATED VACCINES
Title (de)
VRFAHREN UND ZUSAMMENSETZUNGEN FÜR DIE MANIPULATION ATTENUIERTE VAKZINE
Title (fr)
PROCEDES ET COMPOSITIONS POUR LA MISE AU POINT DE VACCINS ATTENUES
Publication
Application
Priority
- US 0016984 W 20000620
- US 34465599 A 19990625
Abstract (en)
[origin: WO0100234A2] This invention provides attenuated vaccines, and methods of obtaining attenuated vaccines. The vaccines of the invention include recombinant viral, bacterial, parasite, and other organisms that are evolved to exhibit increased attenuation without loss of effectiveness as a vaccine. The methods involve the creation of libraries of recombinant nucleic acids (e.g., whole or partial genomes, or particular nucleic acids) which are introduced into the vaccine viruses or other organisms, followed by screening and/or selection for those viruses or organisms that are attenuated.
IPC 1-7
IPC 8 full level
C12N 15/09 (2006.01); A61K 39/00 (2006.01); A61K 39/12 (2006.01); A61K 39/145 (2006.01); A61K 39/155 (2006.01); A61K 39/21 (2006.01); A61K 39/255 (2006.01); A61K 39/265 (2006.01); A61K 39/29 (2006.01); A61K 39/295 (2006.01); A61P 31/00 (2006.01); C12N 7/04 (2006.01); C12Q 1/68 (2006.01)
CPC (source: EP US)
A61K 39/00 (2013.01 - EP US); A61K 39/12 (2013.01 - EP); A61K 39/145 (2013.01 - EP); A61K 39/155 (2013.01 - EP); A61K 39/21 (2013.01 - EP); A61K 39/255 (2013.01 - EP); A61K 39/265 (2013.01 - EP); A61K 39/29 (2013.01 - EP); A61P 31/00 (2018.01 - EP); C12N 7/00 (2013.01 - EP); A61K 2039/5254 (2013.01 - EP); A61K 2039/53 (2013.01 - EP); C12N 2710/16034 (2013.01 - EP); C12N 2710/16334 (2013.01 - EP); C12N 2720/12334 (2013.01 - EP); C12N 2740/16034 (2013.01 - EP); C12N 2760/16134 (2013.01 - EP); C12N 2760/18534 (2013.01 - EP); C12N 2770/10034 (2013.01 - EP); C12N 2770/12034 (2013.01 - EP); C12N 2770/20034 (2013.01 - EP); C12N 2770/24134 (2013.01 - EP); C12N 2770/24161 (2013.01 - EP); C12N 2770/32434 (2013.01 - EP); C12N 2770/36034 (2013.01 - EP); Y02A 50/30 (2018.01 - EP)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0100234 A2 20010104; WO 0100234 A3 20010802; AU 5880900 A 20010131; CA 2377084 A1 20010104; EP 1196552 A2 20020417; JP 2003503039 A 20030128
DOCDB simple family (application)
US 0016984 W 20000620; AU 5880900 A 20000620; CA 2377084 A 20000620; EP 00944760 A 20000620; JP 2001505941 A 20000620