Global Patent Index - EP 1198461 A2

EP 1198461 A2 20020424 - METHOD OF DESIGNING TUBULIN POLYMERIZATION STABILIZERS

Title (en)

METHOD OF DESIGNING TUBULIN POLYMERIZATION STABILIZERS

Title (de)

VERFAHREN ZUM ENTWURF VON TUBULIN POLYMERISATION STABILISATOREN

Title (fr)

CONCEPTION DE STABILISATEURS DE POLYMERISATION DE LA TUBULINE

Publication

EP 1198461 A2 20020424 (EN)

Application

EP 00947487 A 20000717

Priority

  • US 0019524 W 20000717
  • US 14397399 P 19990715
  • US 17189299 P 19991223

Abstract (en)

[origin: WO0105779A2] A method for designing paclitaxel alternative compounds which stabilize the tubulin polymerization process has been found. These compounds in solution possess steric conformational properties of natural paclitaxel and are capable of binding to the tubulin protein at the same site where paclitaxel is known to bind. The compounds of the present invention stabilize tubulin polymerization in a way that is mechanistically equivalent to activity mechanism of paclitaxel. The compounds of the present invention have increased solubility, simpler synthesis, and the possibility for specificity and optimization due to the combinatorial reactions over natural paclitaxel.

IPC 1-7

C07D 305/00

IPC 8 full level

C07C 233/58 (2006.01); C07C 233/87 (2006.01); C07C 235/14 (2006.01); C07C 271/22 (2006.01)

CPC (source: EP)

C07C 233/58 (2013.01); C07C 233/87 (2013.01); C07C 235/14 (2013.01); C07C 271/22 (2013.01); C07C 2602/44 (2017.04)

Citation (search report)

See references of WO 0105779A2

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL

DOCDB simple family (publication)

WO 0105779 A2 20010125; WO 0105779 A3 20010816; AU 6108300 A 20010205; CA 2379676 A1 20010125; EP 1198461 A2 20020424

DOCDB simple family (application)

US 0019524 W 20000717; AU 6108300 A 20000717; CA 2379676 A 20000717; EP 00947487 A 20000717