EP 1200133 A4 20030528 - MANIPULATION OF TISSUE OR ORGAN TYPE USING THE NOTCH PATHWAY
Title (en)
MANIPULATION OF TISSUE OR ORGAN TYPE USING THE NOTCH PATHWAY
Title (de)
MANIPULATION DES GEWEBE- ODER ORGANTYPS MITTELS NOTCH-SIGNALWEG
Title (fr)
MANIPULATION DE TYPE DE TISSU OU D'ORGANE PAR UTILISATION DE LA VOIE NOTCH
Publication
Application
Priority
US 9915727 W 19990712
Abstract (en)
[origin: WO0103743A1] The present invention is directed to methods for altering the fate of a cell, tissue or organ type by altering Notch pathway function in the cell. The invention is further directed to methods for altering the fate of a cell, tissue or organ type by simultaneously changing the activation state of the Notch pathway and one or more cell fate control gene pathways. The invention can be utilized for cells of any differentiation state. The resulting cells may be expanded and used in cell replacement therapy to repopulate lost cell populations and help in the regeneration of diseased and/or injured tissues. The resulting cell populations can also be made recombinant and used for gene therapy or as tissue/organ models for research. The invention is directed to methods for treating macular degeneration comprising altering Notch pathway function in retinal pigment epithelium cells or retinal neuroepithelium or both tissues. The present invention is also directed to kits utilizing the methods of the invention to generate cells, tissues or organs of altered fates. The invention also provides methods for screening for agonists or antagonists of Notch or cell fate control gene pathway functions.
IPC 1-7
IPC 8 full level
A61K 31/7115 (2006.01); A61K 31/712 (2006.01); A61K 31/7125 (2006.01); A61K 31/713 (2006.01); A61K 35/12 (2006.01); A61K 35/76 (2006.01); A61K 38/00 (2006.01); A61K 38/17 (2006.01); A61K 45/00 (2006.01); A61K 48/00 (2006.01); A61P 21/00 (2006.01); A61P 25/00 (2006.01); A61P 25/14 (2006.01); A61P 25/28 (2006.01); A61P 25/30 (2006.01); A61P 27/02 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01); C12N 5/00 (2006.01); C12N 5/06 (2006.01); C12N 5/10 (2006.01); C12N 15/09 (2006.01); C12Q 1/02 (2006.01); G01N 33/15 (2006.01); G01N 33/50 (2006.01)
CPC (source: EP)
A61K 38/1709 (2013.01); A61K 38/1767 (2013.01); A61K 38/177 (2013.01); A61P 21/00 (2017.12); A61P 25/00 (2017.12); A61P 25/14 (2017.12); A61P 25/28 (2017.12); A61P 25/30 (2017.12); A61P 27/02 (2017.12); A61P 35/00 (2017.12); A61P 43/00 (2017.12); C12N 5/0018 (2013.01); G01N 33/5041 (2013.01); C12N 2501/42 (2013.01); C12N 2503/02 (2013.01); Y02A 50/30 (2017.12)
Citation (search report)
- [A] US 5780300 A 19980714 - ARTAVANIS-TSAKONAS SPYRIDON [US], et al
- [A] WO 9848829 A1 19981105 - UNIV ROCKEFELLER [US], et al
- [A] FORTINI MARK E ET AL: "An activated notch receptor blocks cell-fate commitment in the developing Drosophila eye.", NATURE (LONDON), vol. 365, no. 6446, 1993, pages 555 - 557, XP001056504, ISSN: 0028-0836
- See references of WO 0103743A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0103743 A1 20010118; AU 4986499 A 20010130; AU 774188 B2 20040617; CA 2378465 A1 20010118; EP 1200133 A1 20020502; EP 1200133 A4 20030528; EP 1772514 A2 20070411; EP 1772514 A3 20070620; JP 2003530820 A 20031021; JP 4652645 B2 20110316
DOCDB simple family (application)
US 9915727 W 19990712; AU 4986499 A 19990712; CA 2378465 A 19990712; EP 07002048 A 19990712; EP 99933914 A 19990712; JP 2001509216 A 19990712