EP 1200415 A1 20020502 - DIAMINO-1,2,4-TRIAZOLE-CARBOXYLIC ACID DERIVATIVES AS GSK-3 INHIBITORS
Title (en)
DIAMINO-1,2,4-TRIAZOLE-CARBOXYLIC ACID DERIVATIVES AS GSK-3 INHIBITORS
Title (de)
DIAMINO-1,2,4-TRIAZOL-CARBONSÄUREDERIVATE ALS GSK-3 INHIBITOREN
Title (fr)
COMPOSES DIAMINO-1,2,4-TRIAZOLE-ACIDE CARBOXYLIQUE ET DERIVES DE CES DERNIERS UTILES EN TANT QU'INHIBITEURS DE GSK-3
Publication
Application
Priority
- EP 0007423 W 20000731
- GB 9918180 A 19990802
Abstract (en)
[origin: WO0109106A1] Pharmaceutical compositions comprising compounds of formula (I), or a pharmaceutically acceptable derivative thereof, and a pharmaceutically acceptable carrier wherein; the R<3>CZ-moiety may be attached to the nitrogen atom at position 1 or the nitrogen atom at position 2; R<1> is hydrogen, alkyl, aryl, aralkyl, aralkenyl or alicyclic; R<2> is hydrogen, alkyl, aryl, aralkyl, aralkenyl or alicyclic, or R<1> and R<2> together with the nitrogen atom to which they are attached may form a heterocyclic ring which ring may be unsubstituted or substituted; R<3> is alkyl, aryl, aralkyl, aryl(Q)alkyl, where Q is O or S, aralkenyl, alicyclic, heteroaryl, heteroaralkyl, arylcarbonylalkyl, alicyclylalkyl, diarylalkyl, or NR<6>R<7>; R<4> is hydrogen, alkyl, aryl, aralkyl, aralkenyl or alicyclic; R<5> is hydrogen, alkyl, aryl, aralkyl, aralkenyl or alicyclic, or R<4> and R<5> together with the nitrogen atom to which they are attached may form a heterocyclic ring which ring may be unsubstituted or substituted; R<6> is hydrogen, aryl or alicyclic; R<7> is hydrogen, aryl or alicyclic, and: Z is oxygen or sulphur; are indicated to be useful in the treatment of conditions associated with a need for inhibition of GSK-3.
IPC 1-7
C07D 249/14; C07D 405/06; C07D 401/06; A61K 31/4196; A61P 7/12
IPC 8 full level
A61K 31/4196 (2006.01); A61P 3/10 (2006.01); A61P 7/12 (2006.01); A61P 25/20 (2006.01); A61P 25/24 (2006.01); A61P 25/28 (2006.01); A61P 43/00 (2006.01); C07D 249/14 (2006.01); C07D 401/06 (2006.01); C07D 401/12 (2006.01); C07D 403/12 (2006.01); C07D 405/06 (2006.01); C07D 405/12 (2006.01); C07D 409/12 (2006.01)
CPC (source: EP)
A61P 3/10 (2017.12); A61P 7/12 (2017.12); A61P 25/20 (2017.12); A61P 25/24 (2017.12); A61P 25/28 (2017.12); A61P 43/00 (2017.12); C07D 249/14 (2013.01); C07D 401/06 (2013.01); C07D 405/06 (2013.01)
Citation (search report)
See references of WO 0109106A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0109106 A1 20010208; AU 6989800 A 20010219; EP 1200415 A1 20020502; GB 9918180 D0 19991006; JP 2003506362 A 20030218
DOCDB simple family (application)
EP 0007423 W 20000731; AU 6989800 A 20000731; EP 00958343 A 20000731; GB 9918180 A 19990802; JP 2001514309 A 20000731