EP 1200567 A1 20020502 - COMPOUNDS AND METHODS FOR IDENTIFYING COMPOUNDS WHICH INHIBIT A NEW CLASS OF ASPARTYL PROTEASES
Title (en)
COMPOUNDS AND METHODS FOR IDENTIFYING COMPOUNDS WHICH INHIBIT A NEW CLASS OF ASPARTYL PROTEASES
Title (de)
VERBINDUNGEN UND VERFAHREN ZUR IDENTIFIZIERUNG VON VERBINDUNGEN, WELCHE EINE NEUE KLASSE VON ASPARTYLPROTEASEN HEMMEN
Title (fr)
COMPOSES ET PROCEDES D'IDENTIFICATION DE COMPOSES QUI INHIBENT UNE NOUVELLE CLASSE D'ASPARTYL PROTEASES
Publication
Application
Priority
- US 0018775 W 20000711
- US 14335599 P 19990712
Abstract (en)
[origin: WO0104277A1] Compounds and methods for designing and identifying compounds which inhibit TFPP-like aspartyl protease enzymes by targeting the aspartic acid residues of the active site or mimicking peptides corresponding to the region surrounding the substrate's cleavage site are provided. Agents identified as inhibitors of TFPP-like aspartyl proteases such as type 4 prepilin peptidases are expected to be useful as anti-bacterial agents and in inhibiting development of drug resistant strains of bacteria.
IPC 1-7
IPC 8 full level
C08K 3/34 (2006.01); C08K 7/00 (2006.01); C08K 9/04 (2006.01); C12N 9/52 (2006.01)
CPC (source: EP)
C08K 3/346 (2013.01); C08K 7/00 (2013.01); C08K 9/04 (2013.01); C12N 9/52 (2013.01)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0104277 A1 20010118; WO 0104277 A9 20020711; CA 2379269 A1 20010118; EP 1200567 A1 20020502; EP 1200567 A4 20030226
DOCDB simple family (application)
US 0018775 W 20000711; CA 2379269 A 20000711; EP 00947169 A 20000711