Global Patent Index - EP 1200576 A2

EP 1200576 A2 20020502 - DNA'S ENCODING PROTEINS WITH SIGNAL PEPTIDES

Title (en)

DNA'S ENCODING PROTEINS WITH SIGNAL PEPTIDES

Title (de)

KODIERENDE NULEINSÄUREN FÜR PROTEINE MIT SIGNALSEQUENZEN

Title (fr)

PROTEINES CODANT DES ADN COMPLEMENTAIRES AVEC DES PEPTIDES-SIGNAL

Publication

EP 1200576 A2 20020502 (EN)

Application

EP 00940691 A 20000621

Priority

  • IB 0000951 W 20000621
  • US 14103299 P 19990625
  • US 46909999 A 19991221

Abstract (en)

[origin: WO0100803A2] The invention provides the genomic sequence of AA4RP, AA4RP cDNAs and AA4RP polypeptides. Further the invention provides polynucleotides including biallelic markers derived from the AA4RP gene and from genomic regions flanking the gene. This invention also provides polynucleotides and methods suitable for genotyping a nucleic acid containing sample for one or more biallelic markers of the invention. Further, the invention provides methods to detect a statistical correlation between a biallelic marker allele and a phenotype and/or between a biallelic marker haplotype and a phenotype. The invention also relates to diagnostic methods for determining whether an individual is at risk of developing a lipid metabolism related disorder and/or a liver related disorder, or whether said individual suffers from a lipid metabolism related disorder and/or a liver related disorder as a result of a polymorphism in the AA4RP gene.

IPC 1-7

C12N 15/10; C12N 9/00; C07K 14/47; C07K 14/705

IPC 8 full level

C07K 14/47 (2006.01); C07K 14/705 (2006.01); C12N 9/00 (2006.01); C12N 15/10 (2006.01); A61K 38/00 (2006.01)

CPC (source: EP)

C07K 14/47 (2013.01); A01K 2217/05 (2013.01); A01K 2217/075 (2013.01); A61K 38/00 (2013.01); C07K 2319/02 (2013.01); C07K 2319/21 (2013.01); C07K 2319/32 (2013.01)

Citation (search report)

See references of WO 0100806A2

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 0100803 A2 20010104; WO 0100803 A3 20011227; AU 5559400 A 20010131; AU 5838200 A 20010131; CA 2368098 A1 20010104; EP 1200576 A2 20020502; WO 0100661 A2 20010104; WO 0100661 A3 20020110; WO 0100806 A2 20010104; WO 0100806 A3 20020110

DOCDB simple family (application)

IB 0001011 W 20000621; AU 5559400 A 20000621; AU 5838200 A 20000621; CA 2368098 A 20000621; EP 00940691 A 20000621; IB 0000951 W 20000621; IB 0001010 W 20000621