EP 1200835 A1 20020502 - METHODS FOR IDENTIFICATION OF COMPOUNDS STIMULATING INSULIN SECRETION
Title (en)
METHODS FOR IDENTIFICATION OF COMPOUNDS STIMULATING INSULIN SECRETION
Title (de)
VERFAHREN ZUM IDENTIFIZIEREN VON VERBINDUNGEN, DIE DIE INSULINAUSSCHÜTTUNG STIMULIEREN
Title (fr)
PROCEDES D'IDENTIFICATION DE COMPOSES STIMULANT LA SECRETION D'INSULINE
Publication
Application
Priority
- SE 0001563 W 20000810
- SE 9902918 A 19990813
Abstract (en)
[origin: WO0113121A1] According to the invention beta -tubulin, as well as a 65 kDa polypeptide present in pancreatic beta -cells, have been identified as molecular targets for sulfonylurea compounds. These findings enable for the identification of new insulin secretagogues. The invention thus relates to the use of sulfonylurea compounds, such as e.g. glibenclamide, in methods for identification of compounds binding the 65 kDa polypeptide or tubulin, or stimulating tubulin polymerization and/or turnover, said compounds thereby stimulating insulin secretion.
IPC 1-7
IPC 8 full level
G01N 33/50 (2006.01); A61K 45/00 (2006.01); A61P 3/10 (2006.01); C07K 14/47 (2006.01); C07K 14/62 (2006.01); C07K 14/705 (2006.01); G01N 33/15 (2006.01); G01N 33/566 (2006.01); G01N 33/74 (2006.01)
CPC (source: EP)
A61P 3/10 (2017.12); C07K 14/47 (2013.01); C07K 14/62 (2013.01); C07K 14/705 (2013.01); G01N 33/74 (2013.01); G01N 2333/62 (2013.01); G01N 2500/00 (2013.01)
Citation (search report)
See references of WO 0113121A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0113121 A1 20010222; AU 6603200 A 20010313; CA 2380983 A1 20010222; EP 1200835 A1 20020502; JP 2003507365 A 20030225; NO 20020576 D0 20020205; NO 20020576 L 20020205; NZ 516788 A 20030725; SE 9902918 D0 19990813
DOCDB simple family (application)
SE 0001563 W 20000810; AU 6603200 A 20000810; CA 2380983 A 20000810; EP 00953612 A 20000810; JP 2001517172 A 20000810; NO 20020576 A 20020205; NZ 51678800 A 20000810; SE 9902918 A 19990813