EP 1202755 A1 20020508 - CARTILAGE OR BONE MATRIX AS A NUCLEIC ACID DELIVERY VEHICLE
Title (en)
CARTILAGE OR BONE MATRIX AS A NUCLEIC ACID DELIVERY VEHICLE
Title (de)
KNORPEL- ODER KNOCHENMATRIX ALS NUKLEINSÄAUREABGABEVORRICHTUNG
Title (fr)
CARTILAGE OU MATRICE OSSEUSE SERVANT DE VEHICULES POUR ADMINISTRER DES ACIDES NUCLEIQUES
Publication
Application
Priority
- US 0020630 W 20000728
- US 36320899 A 19990728
- US 58599700 A 20000602
Abstract (en)
[origin: WO0108714A1] The present invention relates to tissues, including but not limited to bone and cartilage implants, as carrier matrices for delivery of biologically active nucleic acids to sites where such tissues are to be implanted. Upon implantation, the nucleic acids associated with the implants are taken up by cells within the implant site and are expressed, to produce growth factors, regenerative factors and the like encoded by the nucleic acids. In this manner, for example, where the nucleic acid encodes bone morphogenetic protein or the like, the rate of bone induction, conduction of healing and the rate of cartilage formation or repair is enhanced, without the attendant need to manufacture, purify, isolate and deliver protein or peptide growth factors.
IPC 1-7
A61L 27/22; A61L 27/36; A61L 27/54; C07K 14/475; C07K 14/51; A61K 48/00
IPC 8 full level
A61B 17/58 (2006.01); A61F 2/28 (2006.01); A61F 2/30 (2006.01); A61F 2/44 (2006.01); A61K 9/00 (2006.01); A61K 31/7088 (2006.01); A61K 47/48 (2006.01); A61K 48/00 (2006.01); A61L 27/00 (2006.01); A61L 27/22 (2006.01); A61L 27/36 (2006.01); A61L 27/54 (2006.01); A61P 19/00 (2006.01); A61P 43/00 (2006.01); A61F 2/00 (2006.01); A61F 2/46 (2006.01)
CPC (source: EP)
A61F 2/28 (2013.01); A61F 2/30756 (2013.01); A61F 2/446 (2013.01); A61K 48/00 (2013.01); A61L 27/227 (2013.01); A61L 27/3608 (2013.01); A61L 27/3612 (2013.01); A61L 27/3645 (2013.01); A61L 27/3683 (2013.01); A61L 27/54 (2013.01); A61P 19/00 (2017.12); A61P 43/00 (2017.12); A61F 2/442 (2013.01); A61F 2/4611 (2013.01); A61F 2002/2817 (2013.01); A61F 2002/2835 (2013.01); A61F 2002/2839 (2013.01); A61F 2002/30224 (2013.01); A61F 2002/30235 (2013.01); A61F 2002/30772 (2013.01); A61F 2002/30774 (2013.01); A61F 2002/30813 (2013.01); A61F 2002/30841 (2013.01); A61F 2002/30866 (2013.01); A61F 2002/30892 (2013.01); A61F 2002/448 (2013.01); A61F 2230/0069 (2013.01); A61L 2300/258 (2013.01); A61L 2300/412 (2013.01); A61L 2430/40 (2013.01)
Citation (search report)
See references of WO 0108714A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0108714 A1 20010208; AU 6499800 A 20010219; CA 2379663 A1 20010208; EP 1202755 A1 20020508; JP 2003505205 A 20030212; MX PA02000877 A 20020806
DOCDB simple family (application)
US 0020630 W 20000728; AU 6499800 A 20000728; CA 2379663 A 20000728; EP 00952271 A 20000728; JP 2001513444 A 20000728; MX PA02000877 A 20000728