EP 1204656 A2 20020515 - A CRYSTALLINE FORM OF 6-HYDROXY-3-(4-¬2-(PIPERIDIN-1-YL) ETHOXY PHENOXY)-2-(4-METHOXYPHENYL) BENZO¬B THIOPHENE HYDROCHLORIDE
Title (en)
A CRYSTALLINE FORM OF 6-HYDROXY-3-(4-¬2-(PIPERIDIN-1-YL) ETHOXY PHENOXY)-2-(4-METHOXYPHENYL) BENZO¬B THIOPHENE HYDROCHLORIDE
Title (de)
EINE KRISTALLINE FORM VON 6-HYDROXY-3-(4-¬2-(PIPERIDIN-1-YL) ETHOXY PHENOXY)-2-(4-METHOXYPHENYL) BENZO¬B THIOPHEN-HYDROCHLORID
Title (fr)
NOUVELLE FORME CRISTALLINE DE CHLORHYDRATE DE 6-HYDROXY-3-(4- 2-(PIPERIDIN-1-YL)ETHOXY PHENOXY)-2-(4-METHOXYPHENYL)BENZO b THIOPHENE
Publication
Application
Priority
- US 0016333 W 20000717
- US 14628699 P 19990729
- US 14757099 P 19990806
- US 14977399 P 19990819
Abstract (en)
[origin: WO0109116A2] The present invention is directed to a novel crystalline hydrate of 6-hydroxy-3-(4-[2-(piperidin-1-yl)ethoxy]phenoxy)-2-(4-methoxyphenyl)benzo[b]thiophene hydrochloride and uses for same, including inhibition of disease states associated with estrogen deprivation including cardiovascular disease, hyperlipidemia, and osteoporosis; and inhibition of other pathological conditions such as endometriosis, uterine fibrosis, estrogen-dependent cancer (including breast and uterine cancer), prostate cancer, benign prostatic hyperplasia, CNS disorders including Alzheimer's disease, prevention of breast cancer, and up-regulating ChAT.
IPC 1-7
IPC 8 full level
A61K 31/4535 (2006.01); A61K 31/566 (2006.01); A61K 31/567 (2006.01); C07D 409/12 (2006.01); A61K 31/57 (2006.01); A61K 38/22 (2006.01); A61K 45/00 (2006.01); A61K 45/06 (2006.01); A61P 3/06 (2006.01); A61P 5/32 (2006.01); A61P 9/00 (2006.01); A61P 15/00 (2006.01); A61P 19/08 (2006.01); A61P 19/10 (2006.01); A61P 25/00 (2006.01); A61P 25/28 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01); C07D 333/64 (2006.01)
CPC (source: EP KR)
A61K 31/4535 (2013.01 - EP); A61K 31/567 (2013.01 - EP); A61K 38/09 (2013.01 - EP); A61K 45/06 (2013.01 - EP); A61P 3/00 (2018.01 - EP); A61P 3/06 (2018.01 - EP); A61P 5/30 (2018.01 - EP); A61P 5/32 (2018.01 - EP); A61P 9/00 (2018.01 - EP); A61P 9/10 (2018.01 - EP); A61P 15/00 (2018.01 - EP); A61P 19/08 (2018.01 - EP); A61P 19/10 (2018.01 - EP); A61P 25/00 (2018.01 - EP); A61P 25/28 (2018.01 - EP); A61P 35/00 (2018.01 - EP); A61P 35/04 (2018.01 - EP); A61P 43/00 (2018.01 - EP); C07D 333/64 (2013.01 - EP); C07D 409/12 (2013.01 - KR)
C-Set (source: EP)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0109116 A2 20010208; WO 0109116 A3 20010517; AR 031073 A1 20030910; AT 502318 A1 20070215; AU 6335600 A 20010219; BE 1013411 A3 20011204; BR 0003209 A 20010320; CA 2314682 A1 20010129; CN 1138770 C 20040218; CN 1288007 A 20010321; CO 5180570 A1 20020730; CZ 20002716 A3 20010516; CZ 299311 B6 20080618; DE 10036854 A1 20010301; DK 200001151 A 20010130; DZ 3060 A1 20040522; EP 1204656 A2 20020515; FI 20001722 A0 20000728; FI 20001722 A 20010130; FR 2796944 A1 20010202; FR 2796944 B1 20030131; GB 0018641 D0 20000913; GB 2352717 A 20010207; GR 1004084 B 20021211; GR 20000100265 A 20010330; HK 1035370 A1 20011123; HR P20000503 A2 20010630; HR P20000503 B1 20080430; HU 0003001 D0 20001028; HU P0003001 A2 20020429; ID 27078 A 20010222; IE 20000605 A1 20010404; IL 137553 A0 20010724; IL 137553 A 20050925; IT 1318660 B1 20030827; IT MI20001759 A0 20000728; IT MI20001759 A1 20020128; JP 2001064277 A 20010313; KR 100697177 B1 20070321; KR 20010049916 A 20010615; LT 2000076 A 20010226; LT 4790 B 20010525; LU 90617 B1 20010615; LV 12623 A 20010320; LV 12623 B 20010720; MD 20000162 A 20010430; MD 2336 F2 20031231; MD 2336 G2 20040630; MX PA00007461 A 20040716; MY 128764 A 20070228; NL 1015821 A1 20010130; NL 1015821 C2 20020103; NO 20003879 D0 20000728; NO 20003879 L 20010130; PE 20010385 A1 20010406; PL 341749 A1 20010212; PT 102502 A 20010131; RO 121851 B1 20080630; SE 0002792 D0 20000728; SE 0002792 L 20010130; SG 91296 A1 20020917; SI 20426 A 20010630; SV 2002000132 A 20020607; TR 200002206 A2 20010321; TW I276437 B 20070321; UA 72885 C2 20050516
DOCDB simple family (application)
US 0016333 W 20000717; AR P000103928 A 20000728; AT 13242000 A 20000728; AU 6335600 A 20000717; BE 200000478 A 20000728; BR 0003209 A 20000728; CA 2314682 A 20000728; CN 00122237 A 20000728; CO 00056521 A 20000727; CZ 20002716 A 20000724; DE 10036854 A 20000728; DK PA200001151 A 20000728; DZ 000126 A 20000729; EP 00950223 A 20000717; FI 20001722 A 20000728; FR 0009969 A 20000728; GB 0018641 A 20000728; GR 2000100265 A 20000728; HK 01106204 A 20010903; HR P20000503 A 20000725; HU P0003001 A 20000728; ID 20000629 D 20000724; IE 20000605 A 20000728; IL 13755300 A 20000727; IT MI20001759 A 20000728; JP 2000228939 A 20000728; KR 20000043651 A 20000728; LT 2000076 A 20000728; LU 90617 A 20000728; LV 000094 A 20000718; MD 20000162 A 20000728; MX PA00007461 A 20000728; MY PI20003453 A 20000728; NL 1015821 A 20000727; NO 20003879 A 20000728; PE 0007572000 A 20000731; PL 34174900 A 20000728; PT 10250200 A 20000728; RO 200000736 A 20000721; SE 0002792 A 20000728; SG 200004288 A 20000728; SI 200000172 A 20000728; SV 2000000132 A 20000728; TR 200002206 A 20000727; TW 89115154 A 20000728; UA 200074563 A 20000728