EP 1206272 A1 20020522 - HYBRID POLYPEPTIDES WITH ENHANCED PHARMACOKINETIC PROPERTIES
Title (en)
HYBRID POLYPEPTIDES WITH ENHANCED PHARMACOKINETIC PROPERTIES
Title (de)
HYBRID-POLYPEPTIDE MIT VERBESSERTEN PHARMAKOKINETISCHEN EIGENSCHAFTEN
Title (fr)
POLYPEPTIDES HYBRIDES POSSEDANT DES PROPRIETES PHARMACOCINETIQUES AMELIOREES
Publication
Application
Priority
- US 0018772 W 20000710
- US 35064199 A 19990709
Abstract (en)
[origin: WO0103723A1] The present invention relates to enhancer peptide sequences originally derived from various retroviral envelope (gp41) protein sequences that enhance the pharmacokinetic properties of any core polypeptide to which they are linked. The invention is based on the discovery that hybrid polypeptides comprising the enhancer peptide sequences linked to a core polypeptide possess enhanced pharmacokinetic properties such as increased half life. The invention further relates to methods for enhancing the pharmacokinetic properties of any core polypeptide through linkage of the enhancer peptide sequences to the core polypeptide. The core polypeptides to be used in the practice of the invention can include any pharmacologically useful peptide that can be used, for example, as a therapeutic or prophylactic reagent.
IPC 1-7
A61K 38/02; A61K 38/08; A61K 38/10; A61K 38/16; A61K 38/18; A61K 38/19; A61K 38/22; C07K 7/06; C07K 7/08; C07K 14/00
IPC 8 full level
A61K 38/00 (2006.01); A61K 38/08 (2019.01); A61K 38/21 (2006.01); A61K 38/27 (2006.01); A61K 47/48 (2006.01); A61P 31/14 (2006.01); A61P 31/16 (2006.01); A61P 31/18 (2006.01); A61P 31/20 (2006.01); C07K 5/113 (2006.01); C07K 5/117 (2006.01); C07K 14/135 (2006.01); C07K 14/15 (2006.01); C07K 14/16 (2006.01); C07K 14/59 (2006.01); C07K 19/00 (2006.01)
CPC (source: EP KR US)
A61K 47/62 (2017.07 - EP US); A61P 31/14 (2017.12 - EP); A61P 31/16 (2017.12 - EP); A61P 31/18 (2017.12 - EP); A61P 31/20 (2017.12 - EP); C07K 5/1021 (2013.01 - EP US); C07K 5/1024 (2013.01 - EP US); C07K 7/08 (2013.01 - KR); C07K 14/005 (2013.01 - EP US); C07K 14/59 (2013.01 - EP US); A61K 38/00 (2013.01 - EP US); C07K 2319/00 (2013.01 - EP US); C12N 2740/16122 (2013.01 - EP US); C12N 2760/18522 (2013.01 - EP US); Y02A 50/30 (2017.12 - EP)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0103723 A1 20010118; WO 0103723 A9 20020725; AR 024699 A1 20021023; AU 6082200 A 20010130; BR 0012287 A 20020402; CA 2377677 A1 20010118; CN 1254271 C 20060503; CN 1373669 A 20021009; CZ 200288 A3 20020612; EP 1206272 A1 20020522; EP 1206272 A4 20030102; HK 1045259 A1 20021122; HR P20020022 A2 20040229; IL 147331 A0 20020814; JP 2003504344 A 20030204; KR 100755418 B1 20070905; KR 20020029667 A 20020419; MX PA02000012 A 20030721; NO 20020087 D0 20020108; NO 20020087 L 20020301; NZ 516550 A 20040528; PL 352685 A1 20030908; RU 2279883 C2 20060720; TR 200200766 T2 20021021; TW I248364 B 20060201; US 2003186874 A1 20031002; US 6656906 B1 20031202; US 7297784 B2 20071120; YU 1402 A 20041125
DOCDB simple family (application)
US 0018772 W 20000710; AR P000103536 A 20000710; AU 6082200 A 20000710; BR 0012287 A 20000710; CA 2377677 A 20000710; CN 00812740 A 20000710; CZ 200288 A 20000710; EP 00947166 A 20000710; HK 02106016 A 20020819; HR P20020022 A 20020109; IL 14733100 A 20000710; JP 2001509199 A 20000710; KR 20027000311 A 20020109; MX PA02000012 A 20000710; NO 20020087 A 20020108; NZ 51655000 A 20000710; PL 35268500 A 20000710; RU 2002103334 A 20000710; TR 200200766 T 20000710; TW 89113675 A 20000805; US 35064199 A 19990709; US 35164103 A 20030124; YU P1402 A 20000710