EP 1207903 A1 20020529 - REDUCTION OF THE IMMUNOGENICITY OF NON-HUMAN GRAFTS
Title (en)
REDUCTION OF THE IMMUNOGENICITY OF NON-HUMAN GRAFTS
Title (de)
VERRINGERUNG DER IMMUNOGENITÄT VON NICHT-MENSCHLICHEN TRANSPLANTATEN
Title (fr)
REDUCTION DE L'IMMUNOGENICITE DE GREFFONS NON HUMAINS
Publication
Application
Priority
- SE 0001648 W 20000828
- SE 9903021 A 19990826
Abstract (en)
[origin: WO0113947A1] The present invention relates to a transplantion material produced by dissociation of porcine tissue and removal of macrophages and/or microglial cells therefrom. The tissue could be an embryonic or fetal neural tissue and the removal could be effected by exposing the preparation above to antibodies against the Gal alpha 1-3Gal beta 1-R epitope and a complement reagent. The invention also relates to the use of such a transplantation material for preparing a pharmaceutical preparation useful when transplanting neural tissue. The invention also relates to a kit comprising one or more enzymes for tissue dissociation, an antibody preparation and a complement reagent. The invention also relates to a process for removal of macrophages and/or microglial cells from porcine embryonic or fetal neural tissue. Finally, the invention relates to a process for treatment of neurological disorders with such pretreated porcine neural grafts.
IPC 1-7
IPC 8 full level
A61F 2/02 (2006.01); A61L 27/00 (2006.01); C07K 16/28 (2006.01)
CPC (source: EP)
C07K 16/28 (2013.01); A61K 2039/505 (2013.01)
Citation (search report)
See references of WO 0113947A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0113947 A1 20010301; AU 7046000 A 20010319; AU 774651 B2 20040701; EP 1207903 A1 20020529; JP 2003507131 A 20030225; SE 9903021 D0 19990826
DOCDB simple family (application)
SE 0001648 W 20000828; AU 7046000 A 20000828; EP 00959076 A 20000828; JP 2001518083 A 20000828; SE 9903021 A 19990826