EP 1207909 A2 20020529 - METHOD FOR COUPLING MOLECULES
Title (en)
METHOD FOR COUPLING MOLECULES
Title (de)
VERFAHREN ZUR KUPLUNG VON MOLEKÜLE
Title (fr)
PROCEDE DE COUPLAGE DE MOLECULES
Publication
Application
Priority
- GB 0003306 W 20000825
- GB 9920397 A 19990827
- GB 0012083 A 20000518
Abstract (en)
[origin: WO0115737A2] A method of linking a first molecule M<1>-NH2 with a second molecule M<2>-OH comprising reaction of a compound of the formula (I): M<1>-NH-CO-A-CO-SR<1> wherein M<1> is the residue of a molecule bearing an amino group, A is an alkylene or arylene group, R<1> is alkyl or aryl, with a compound of formula (II), M<2> is the residue of a molecule bearing a hydroxy group wherein B is a linker, D is C1-4 alkylene group or C3-12 arylene group, R<2> is hydrogen or a thiol protecting group. In addition, this invention relates to conjugate products of the coupling reaction, reagents for modifying M<1>-NH2 and M<2>-OH, and kits comprising these reagents.
IPC 1-7
IPC 8 full level
A61K 31/7088 (2006.01); A61K 47/48 (2006.01); A61K 48/00 (2006.01); A61P 43/00 (2006.01); C07K 1/00 (2006.01); C07K 7/00 (2006.01); C07K 14/00 (2006.01)
CPC (source: EP)
A61K 47/65 (2017.07); A61P 43/00 (2017.12)
Citation (search report)
See references of WO 0115737A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0115737 A2 20010308; WO 0115737 A3 20011115; AU 6853900 A 20010326; CA 2382499 A1 20010308; EP 1207909 A2 20020529; JP 2003508450 A 20030304
DOCDB simple family (application)
GB 0003306 W 20000825; AU 6853900 A 20000825; CA 2382499 A 20000825; EP 00956666 A 20000825; JP 2001520148 A 20000825