EP 1209971 A4 20040414 - CHARGE REVERSAL OF POLYION COMPLEXES
Title (en)
CHARGE REVERSAL OF POLYION COMPLEXES
Title (de)
LADUNGSWECHSEL VON POLYION-KOMPLEXEN
Title (fr)
INVERSION DE CHARGE DE COMPLEXES DE POLYIONS
Publication
Application
Priority
- US 0022832 W 20000818
- US 15016099 P 19990820
Abstract (en)
[origin: WO0113723A1] An ionic polymer is utilized in "recharging" (another layer having a different charge) a condensed polynucleotide complex for purposes of nucleic acid delivery to a cell. The resulting recharged complex can be formed with an appropriate amount of positive or negative charge such that the resulting complex has the desired net charge.
IPC 1-7
IPC 8 full level
A61K 47/48 (2006.01); C12N 15/88 (2006.01); A61K 48/00 (2006.01)
CPC (source: EP)
A61K 47/58 (2017.07); A61K 47/59 (2017.07); A61K 47/60 (2017.07); A61K 47/645 (2017.07); C12N 15/88 (2013.01); A61K 48/00 (2013.01)
Citation (search report)
- [X] US 5935599 A 19990810 - DADEY ERIC J [US]
- [PX] WO 0003694 A1 20000127 - MIRUS CORP [US]
- [X] ROSS PC ET AL.: "Lipoplex size is a major determinant of in vitro lipofection efficiency", GENE THERAPY, vol. 6, no. 4, April 1999 (1999-04-01), pages 651 - 659, XP002270219
- [X] VITIELLO ET AL.: "Condensation of plasmid DNA with polylysine improves liposome-mediated gene transfer into established and primary muscle cells", GENE THERAPY, vol. 3, 1996, pages 396 - 404, XP009025639
- See references of WO 0113723A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0113723 A1 20010301; EP 1209971 A1 20020605; EP 1209971 A4 20040414
DOCDB simple family (application)
US 0022832 W 20000818; EP 00955747 A 20000818