EP 1210093 A4 20050112 - DEGRADABLE POLYMERS
Title (en)
DEGRADABLE POLYMERS
Title (de)
ABBAUBARE POLYMERE
Title (fr)
POLYMERES DEGRADABLES
Publication
Application
Priority
- EP 00961523 A 20000901
- EP 99307041 A 19990903
- US 0024232 W 20000901
Abstract (en)
[origin: WO0117515A1] A polymer comprising: a polymeric backbone comprising at least one unit having the structure (I), wherein R-R<4> comprise groups selected from the group consisting of H, C1-C12 alkyl, C6-C18 aryl, C7-C18 aralkyl, C6-C18 cycloalkyl or any of the group consisting of C1-C12 alkyl, C6-C18 aryl, C7-C18 aralkyl, C6-C18 cycloalkyl substituted, within the carbon chain or appended thereto, with one or more heteroatoms; R and R<2> or R and R<4> or R and R<1> or R<2> and R<3> may be joined so that with the carbon atom(s) to which they are attached they together form a saturated, partially unsaturated or unsaturated ring system respectively, may have a pendent group which may incorporate a linker unit, (for example a peptide linkage) or a unit having the structure (I); A comprises a proton donating moiety selected from the group consisting of formula (1). B comprises a hydrolytically labile group and is selected from the group consisting of formula (2), wherein each R<5> is individually selected from the group consisting of H, C1-C12 alkyl, C6-C18 aryl, C7-C18 aralkyl, C6-C18 cycloalkyl; wherein groups A and B are in a cis-configuration about bond Ca-Cb; m is an integer of 0 to 100, n, p and q are each an integer of 0 or 1; Q comprises 1 or more structures selected from the group consisting of formula (3) wherein R<6>-R<11> are individually selected from the same group as defined for group R above and r is an integer between 1 and 5000, preferably 1 to 10, most preferably 1 to 6; methods for the production, and uses thereof.
IPC 1-7
IPC 8 full level
A61K 47/48 (2006.01); A61K 31/337 (2006.01); A61K 31/704 (2006.01); A61P 35/00 (2006.01); C08G 63/00 (2006.01); C08G 65/329 (2006.01); C08G 65/332 (2006.01); C08G 65/333 (2006.01); C08G 69/34 (2006.01); C08G 69/40 (2006.01); C08G 69/48 (2006.01)
CPC (source: EP)
A61P 35/00 (2017.12); C08G 63/00 (2013.01); C08G 69/34 (2013.01)
Citation (search report)
- [DA] GB 2270920 A 19940330 - UNIV KEELE [GB]
- [A] ABUCHOWSKI A ET AL: "CANCER THERAPY WITH CHEMICALLY MODIFIED ENZYMES. I. ANTITUMOR PROPERTIES OF POLYETHYLENE GLYCOL-ASPARAGINASE CONJUGATES", 1984, CANCER BIOCHEMISTRY BIOPHYSICS,US,GORDON AND BREACH SCIENCE PUBLISHER, INC, VOL. 7, PAGE(S) 175-186, ISSN: 0305-7232, XP000199119
- See references of WO 0117515A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0117515 A1 20010315; AU 7346400 A 20010410; EP 1210093 A1 20020605; EP 1210093 A4 20050112; JP 2003528939 A 20030930
DOCDB simple family (application)
US 0024232 W 20000901; AU 7346400 A 20000901; EP 00961523 A 20000901; JP 2001521306 A 20000901