Global Patent Index - EP 1210109 A2

EP 1210109 A2 20020605 - UTILIZATION OF AT LEAST ONE AMINOPEPTIDASE INHIBITOR

Title (en)

UTILIZATION OF AT LEAST ONE AMINOPEPTIDASE INHIBITOR

Title (de)

VERWENDUNG MINDESTENS EINES AMINOPEPTIDASEN-INHIBITORS

Title (fr)

UTILISATION D'AU MOINS UN INHIBITEUR D'AMINOPEPTIDASE

Publication

EP 1210109 A2 20020605 (DE)

Application

EP 01911521 A 20010124

Priority

  • DE 10002820 A 20000124
  • EP 0100746 W 20010124

Abstract (en)

[origin: WO0154707A2] The invention concerns the utilization of at least one aminopeptidase inhibitor for the production of a medicament used in the treatment of tumor diseases and/or immune diseases, whereby the at least one aminopeptidase inhibitor causes blocking of polarization of invasive human or animal tumor and/or immune cells by modifying at least one surface protein CD13 as member of a protein network on the surface of the tumor and/or immune cell, whereby the protein network comprises up to 30 surface proteins from a defined group. The invention also concerns a pharmaceutical preparation and a method for identifying at least one additional inhibitor acting in combination with the at least one aminopeptidase inhibitor.

IPC 1-7

A61K 38/48; A61K 31/40; G01N 33/574; G01N 33/50; A61P 35/00; A61P 37/00

IPC 8 full level

A61K 31/00 (2006.01); A61K 31/40 (2006.01); A61K 39/395 (2006.01); A61K 45/00 (2006.01); A61P 35/00 (2006.01); A61P 37/00 (2006.01); A61P 37/06 (2006.01); A61P 37/08 (2006.01); C12Q 1/37 (2006.01); G01N 33/15 (2006.01); G01N 33/50 (2006.01); G01N 33/53 (2006.01); G01N 33/566 (2006.01); G01N 33/574 (2006.01)

CPC (source: EP US)

A61K 31/00 (2013.01 - EP US); A61K 31/40 (2013.01 - EP US); A61P 35/00 (2017.12 - EP); A61P 37/00 (2017.12 - EP); A61P 37/06 (2017.12 - EP); A61P 37/08 (2017.12 - EP); G01N 33/5011 (2013.01 - EP US); G01N 33/5047 (2013.01 - EP US); G01N 33/57492 (2013.01 - EP US)

Citation (search report)

See references of WO 0154707A2

Citation (examination)

  • WO 9844923 A1 19981015 - SLOAN KETTERING INST CANCER [US], et al
  • EP 0167936 A2 19860115 - MICROBIAL CHEM RES FOUND [JP]
  • YAMAZAKI ET AL: "Effect of ubenimex on the immune system of patients with hematologic malignancies", BIOMEDICINE & PHARMACOTHERAPY, vol. 45, no. 2-3, 1991, pages 105 - 112, XP000999659
  • KAGECHIKA ET AL: "Potent homophthalimide-type inhibitors of B16F10/L5 mouse melanoma cell invasion", BIOLOGICAL PHARMACEUTICAL BULLETIN, vol. 22, no. 9, 1999, pages 1010 - 1012, XP000986267
  • LENDECKEL ET AL: "Inhibition of alanyl aminopeptidase induces MAP-kinase p42/ERK42 in the human T cell line KARPAS 299", BIOCHEMICAL BIOPHYSICAL RESEARCH, vol. 252, no. 1, 1998, pages 5 - 9, XP000999102

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

DOCDB simple family (publication)

WO 0154707 A2 20010802; WO 0154707 A3 20020314; CN 1358099 A 20020710; DE 10002820 A1 20010823; EP 1210109 A2 20020605; EP 1510219 A1 20050302; JP 2003520821 A 20030708; SG 119168 A1 20060228; US 2003130180 A1 20030710; US 2006263373 A1 20061123

DOCDB simple family (application)

EP 0100746 W 20010124; CN 01800106 A 20010124; DE 10002820 A 20000124; EP 01911521 A 20010124; EP 04024180 A 20010124; JP 2001554691 A 20010124; SG 200300072 A 20010124; US 49262306 A 20060725; US 93719102 A 20020103