Global Patent Index - EP 1210426 A2

EP 1210426 A2 20020605 - POLYMORPHISMS IN A KLOTHO GENE

Title (en)

POLYMORPHISMS IN A KLOTHO GENE

Title (de)

POLYMORPHISMEN EINES KLOTHO-GENS

Title (fr)

POLYMORPHISMES DANS UN GENE KLOTHO

Publication

EP 1210426 A2 20020605 (EN)

Application

EP 00958842 A 20000908

Priority

  • GB 0003457 W 20000908
  • GB 9921485 A 19990910
  • GB 0006171 A 20000314

Abstract (en)

[origin: WO0120031A2] Methods and means are described for diagnosing a disease or a predisposition to disease by genotyping a <i>klotho</i> gene from an individual and identifying the presence of one or more risk polymorphisms. These risk polymorphisms are associated either directly or indirectly with predisposition to a range of chronic diseases including osteoporosis, skin disorders, age-related disease, lung dysfunction and metabolic syndrome. Methods of treatment, kits for diagnostic purposes and an isolated <i>klotho</i> gene including all or some of a range of polymorphisms are also described as well as methods of isolating molecules that modulate a <i>klotho</i> gene.

IPC 1-7

C12N 15/12; C12Q 1/68; C12N 15/63; C07K 14/47

IPC 8 full level

C12N 15/09 (2006.01); A61K 38/22 (2006.01); A61K 45/00 (2006.01); A61P 3/00 (2006.01); A61P 3/04 (2006.01); A61P 9/00 (2006.01); A61P 11/00 (2006.01); A61P 17/00 (2006.01); A61P 19/08 (2006.01); A61P 19/10 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01); C07K 14/47 (2006.01); C12N 1/15 (2006.01); C12N 1/19 (2006.01); C12N 1/21 (2006.01); C12N 5/10 (2006.01); C12P 21/02 (2006.01); C12Q 1/68 (2006.01)

CPC (source: EP)

A61P 3/00 (2017.12); A61P 3/04 (2017.12); A61P 9/00 (2017.12); A61P 11/00 (2017.12); A61P 17/00 (2017.12); A61P 19/08 (2017.12); A61P 19/10 (2017.12); A61P 35/00 (2017.12); A61P 43/00 (2017.12); C07K 14/47 (2013.01); C12Q 1/6883 (2013.01); C12Q 2600/156 (2013.01); C12Q 2600/158 (2013.01); C12Q 2600/172 (2013.01)

Citation (search report)

See references of WO 0120031A2

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 0120031 A2 20010322; WO 0120031 A3 20020314; AU 7025700 A 20010417; EP 1210426 A2 20020605; JP 2003514513 A 20030422

DOCDB simple family (application)

GB 0003457 W 20000908; AU 7025700 A 20000908; EP 00958842 A 20000908; JP 2001523802 A 20000908