EP 1210444 A2 20020605 - ISOFORMS OF SNARE MOLECULES AND THE USES THEREOF IN MODULATION OF CELLULAR EXOCYTOSIS
Title (en)
ISOFORMS OF SNARE MOLECULES AND THE USES THEREOF IN MODULATION OF CELLULAR EXOCYTOSIS
Title (de)
ISOFORMEN VON SNARE-MOLEKÜLEN UND IHRE ANWENDUNGEN ZUR MODULATION ZELLULÄRER EXOZYTOSE
Title (fr)
ISOFORMES DE MOLECULES DE SNARE ET LEURS UTILISATIONS POUR MODULER L'EXOCYTOSE CELLULAIRE
Publication
Application
Priority
- GB 0003196 W 20000818
- US 14999399 P 19990820
Abstract (en)
[origin: WO0118038A2] A method of treating a patient suffering from poisoning by clostridial toxin wherein a SNARE (soluble (<i>N</i>-ethylmaleimide-sensitive fusion protein)-attachment protein receptor) that is resistant to proteolysis by the said clostridial toxin (toxin-resistant SNARE) and/or is capable of inhibiting the clostridial toxin is supplied to a cell of the patient. The SNARE that is resistant to proteolysis may be, synaptosomal-associated polypeptide of 25 kDA (SNAP-25). The SNAP-25 is preferably resistant to proteolysis by BoNT/A, BoNT/E and BoNT/C. A method of treating a patient in need of inhibition of SNARE-dependent exocytosis from a cell capable of performing SNARE-dependent exocytosis wherein a derivative (inhibitory SNARE) that is capable of inhibiting SNARE-dependent exocytosis is supplied to the said cell of the patient. The inhibitory SNARE may be a fragment of SNAP-25 that is derivable by cleavage of SNAP-25 by botulinum toxin A (BoNT/A). The cell may be, for example, a nerve cell, adreno-chromaffin cell or insulin-secreting cell. The SNARE may be supplied to the cell by expressing recombinant polynucleotide construct. The SNARE or construct may be targeted to a nerve cell, by means of an inactive clostridial neurotoxin. The SNARE may be expressed under the target cell-specific promoter.
IPC 1-7
IPC 8 full level
A61K 38/00 (2006.01); A61K 48/00 (2006.01); A61P 31/04 (2006.01); A61P 39/02 (2006.01); C07K 14/47 (2006.01); C07K 14/705 (2006.01); C12N 15/09 (2006.01); C12P 21/02 (2006.01)
CPC (source: EP)
A61P 31/04 (2017.12); A61P 39/02 (2017.12); C07K 14/705 (2013.01); A61K 38/00 (2013.01); A61K 48/00 (2013.01); Y02A 50/30 (2017.12)
Citation (search report)
See references of WO 0118038A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0118038 A2 20010315; WO 0118038 A3 20011011; AU 6852600 A 20010410; AU 781226 B2 20050512; CA 2379532 A1 20010315; EP 1210444 A2 20020605; JP 2003508092 A 20030304
DOCDB simple family (application)
GB 0003196 W 20000818; AU 6852600 A 20000818; CA 2379532 A 20000818; EP 00956652 A 20000818; JP 2001522260 A 20000818