EP 1210578 A4 20070221 - METHODS AND APPARATUSES FOR STRETCHING POLYMERS

Title (en)

METHODS AND APPARATUSES FOR STRETCHING POLYMERS

Title (de)

VERFAHREN UND APPARATE ZUR DEHNUNG VON POLYMEREN

Title (fr)

PROCEDE ET APPAREIL D'ETIRAGE DE POLYMERES

Publication

EP 1210578 A4 20070221 (EN)

Application

EP 00955515 A 20000811

Priority

US 0022253 W 20000811
US 14902099 P 19990813

Abstract (en)

[origin: WO0113088A1] The present invention provides structures and methods that allow polymers of any length, including nucleic acids containing entire genomes, to be stretched into a long, linear conformation for further analysis. The present invention also provides structures and methods for selecting and stretching polymers based on their lengths. Polymers are loaded into a device and run through the structures. Stretching is achieved by, <i>e.g.</i>, applying shear forces as the polymer passes through the structures, placing obstacles in the path of the polymer, or a combination thereof. Since multiple molecules may be stretched in succession, extremely high throughput screening, <i>e.g.</i>, screening of more than one molecule per second, is achieved.

IPC 8 full level

B01L 3/00 (2006.01); G01N 33/50 (2006.01); B01F 5/06 (2006.01); C12M 1/00 (2006.01); C12M 1/42 (2006.01); C12Q 1/68 (2006.01); G01N 1/28 (2006.01); G01N 37/00 (2006.01); C12Q 1/6869 (2018.01); G01N 33/44 (2006.01)

CPC (source: EP)

B01F 25/431 (2022.01); B01F 25/432 (2022.01); B01F 25/433 (2022.01); B01L 3/502746 (2013.01); B01L 3/502761 (2013.01); B01L 3/502776 (2013.01); B01L 2200/0647 (2013.01); B01L 2200/0663 (2013.01); B01L 2200/0694 (2013.01); B01L 2300/0681 (2013.01); B01L 2300/0883 (2013.01); B01L 2400/086 (2013.01); C12Q 1/6869 (2013.01); G01N 33/442 (2013.01)

Citation (search report)

[PX] WO 0009757 A1 20000224 - U S GENOMICS [US], et al
[A] WO 9909042 A2 19990225 - CEPHEID [US]
[A] US 5538898 A 19960723 - WICKRAMASINGHE HEMANTHA K [US], et al
See references of WO 0113088A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 0113088 A1 20010222; AU 6771100 A 20010313; CA 2381361 A1 20010222; CN 1379857 A 20021113; EP 1210578 A1 20020605; EP 1210578 A4 20070221; IL 148088 A0 20020912; JP 2003507026 A 20030225

DOCDB simple family (application)

US 0022253 W 20000811; AU 6771100 A 20000811; CA 2381361 A 20000811; CN 00814266 A 20000811; EP 00955515 A 20000811; IL 14808800 A 20000811; JP 2001517140 A 20000811