EP 1211309 A8 20021120 - METHOD AND APPARATUS FOR PROLIFERATING HEPATITIS VIRUS
Title (en)
METHOD AND APPARATUS FOR PROLIFERATING HEPATITIS VIRUS
Title (de)
VERFAHREN UND VORRICHTUNG ZUR VERMEHRUNG VON HEPATITISVIREN
Title (fr)
PROCEDE ET APPAREIL DE PROLIFERATION DU VIRUS DE L'HEPATITE
Publication
Application
Priority
- JP 0005582 W 20000821
- JP 23364799 A 19990820
Abstract (en)
[origin: EP1211309A1] A method for proliferating a hepatitis virus such as HCV and an apparatus therefor. A method of proliferating cells (for example, hepatocytes), which are less adhesive to a carrier, in a large amount over a long time. More particularly, the above method comprises infecting hepatocytes, which are maintained in a radial flow type hepatocyte bioreactor consisting of a main bioreactor unit containing the hepatocytes carried on a particulate porous carrier and a liquid culture medium flown from the periphery of the main bioreactor unit toward the center thereof, with a hepatitis virus; continuously flowing the liquid culture medium from the periphery of the main bioreactor unit toward the center thereof; and thus proliferating the hepatitis virus in the hepatocytes thus infected. <IMAGE>
IPC 1-7
IPC 8 full level
C12M 1/40 (2006.01); C12M 3/00 (2006.01); C12M 3/02 (2006.01); C12N 7/00 (2006.01)
CPC (source: EP)
C12M 25/16 (2013.01); C12M 41/00 (2013.01); C12N 7/00 (2013.01); C12N 2770/24251 (2013.01)
Citation (search report)
See references of WO 0114517A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
EP 1211309 A1 20020605; EP 1211309 A4 20030212; EP 1211309 A8 20021120; JP 4146124 B2 20080903; WO 0114517 A1 20010301
DOCDB simple family (application)
EP 00953532 A 20000821; JP 0005582 W 20000821; JP 2001518833 A 20000821