Global Patent Index - EP 1211309 A8

EP 1211309 A8 20021120 - METHOD AND APPARATUS FOR PROLIFERATING HEPATITIS VIRUS

Title (en)

METHOD AND APPARATUS FOR PROLIFERATING HEPATITIS VIRUS

Title (de)

VERFAHREN UND VORRICHTUNG ZUR VERMEHRUNG VON HEPATITISVIREN

Title (fr)

PROCEDE ET APPAREIL DE PROLIFERATION DU VIRUS DE L'HEPATITE

Publication

EP 1211309 A8 20021120 (EN)

Application

EP 00953532 A 20000821

Priority

  • JP 0005582 W 20000821
  • JP 23364799 A 19990820

Abstract (en)

[origin: EP1211309A1] A method for proliferating a hepatitis virus such as HCV and an apparatus therefor. A method of proliferating cells (for example, hepatocytes), which are less adhesive to a carrier, in a large amount over a long time. More particularly, the above method comprises infecting hepatocytes, which are maintained in a radial flow type hepatocyte bioreactor consisting of a main bioreactor unit containing the hepatocytes carried on a particulate porous carrier and a liquid culture medium flown from the periphery of the main bioreactor unit toward the center thereof, with a hepatitis virus; continuously flowing the liquid culture medium from the periphery of the main bioreactor unit toward the center thereof; and thus proliferating the hepatitis virus in the hepatocytes thus infected. <IMAGE>

IPC 1-7

C12M 3/00; C12N 7/00

IPC 8 full level

C12M 1/40 (2006.01); C12M 3/00 (2006.01); C12M 3/02 (2006.01); C12N 7/00 (2006.01)

CPC (source: EP)

C12M 25/16 (2013.01); C12M 41/00 (2013.01); C12N 7/00 (2013.01); C12N 2770/24251 (2013.01)

Citation (search report)

See references of WO 0114517A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

EP 1211309 A1 20020605; EP 1211309 A4 20030212; EP 1211309 A8 20021120; JP 4146124 B2 20080903; WO 0114517 A1 20010301

DOCDB simple family (application)

EP 00953532 A 20000821; JP 0005582 W 20000821; JP 2001518833 A 20000821