EP 1212039 B1 20051102 - COMPOSITION FOR INHALATION COMPRISING DELTA-9-TETRAHYDROCANNABINOL IN A SEMIAQUEOUS SOLVENT
Title (en)
COMPOSITION FOR INHALATION COMPRISING DELTA-9-TETRAHYDROCANNABINOL IN A SEMIAQUEOUS SOLVENT
Title (de)
ZUSAMMENSETZUNG FÜR INHALIERUNG ENTHALTEND DELTA-9-TETRAHYDROCANNABINOL IN EINEM SEMI-WÄSSRIGEN LÖSUNGSMITTEL
Title (fr)
COMPOSITION POUR INHALATION COMPRENANT DU DELTA-9-TETRAHYDROCANNABINOL DANS UN SOLVANT SEMI-AQUEUX
Publication
Application
Priority
- US 0022495 W 20000815
- US 15002399 P 19990820
Abstract (en)
[origin: WO0113886A1] A formulation of delta-9-tetrahydrocannabinol in a semi-aqueous solvent, such as 35:10:55 alcohol:water:propylene glycol (v/v), produces a stable clear solution near the solubility point of the drug. Because delta-9-tetrahydrocannabinol has poor affinity for the formulation, it is able to partition out and transport across cell membranes to reach the bloodstream quickly. This has been demonstrated by the comparative tmax values achieved in single dose intravenous and 14 day multiple dose inhalation studies conducted in dogs and rats.
IPC 1-7
IPC 8 full level
A61K 9/12 (2006.01); A61K 9/00 (2006.01); A61K 31/352 (2006.01); A61K 47/10 (2006.01); A61P 1/08 (2006.01); A61P 1/14 (2006.01)
CPC (source: EP)
A61K 9/0078 (2013.01); A61K 9/008 (2013.01); A61K 31/352 (2013.01); A61P 1/08 (2018.01); A61P 1/14 (2018.01)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0113886 A1 20010301; AT E308314 T1 20051115; AU 6910700 A 20010319; AU 779324 B2 20050120; CA 2382217 A1 20010301; CN 1187093 C 20050202; CN 1420761 A 20030528; DE 60023720 D1 20051208; DE 60023720 T2 20060720; DK 1212039 T3 20051219; EP 1212039 A1 20020612; EP 1212039 B1 20051102; ES 2246883 T3 20060301; HK 1056318 A1 20040213; IL 148241 A0 20020912; IL 148241 A 20070211; JP 2003535813 A 20031202; MX PA02001804 A 20040906; NO 20020835 D0 20020220; NO 20020835 L 20020402; NZ 517517 A 20040326
DOCDB simple family (application)
US 0022495 W 20000815; AT 00957496 T 20000815; AU 6910700 A 20000815; CA 2382217 A 20000815; CN 00813195 A 20000815; DE 60023720 T 20000815; DK 00957496 T 20000815; EP 00957496 A 20000815; ES 00957496 T 20000815; HK 03108637 A 20031126; IL 14824100 A 20000815; IL 14824102 A 20020219; JP 2001518025 A 20000815; MX PA02001804 A 20000815; NO 20020835 A 20020220; NZ 51751700 A 20000815