EP 1212306 A2 20020612 - HYDROXYALKANOYLAMINOLACTAMS AND RELATED STRUCTURES AS INHIBITORS OF ABETA PROTEIN PRODUCTION
Title (en)
HYDROXYALKANOYLAMINOLACTAMS AND RELATED STRUCTURES AS INHIBITORS OF ABETA PROTEIN PRODUCTION
Title (de)
HYDROXYALKANOYLAMINOLACTAME UND ANVERWANDTE STRUKTUREN ALS PRODUKTIONS-INHIBITOREN VON ABETA PROTEINEN
Title (fr)
HYDROXYALKANOYL AMINOLACTAMES ET STRUCTURES ASSOCIEES, INHIBITEURS DE LA PRODUCTION DE LA PROTEINE A$g(b)
Publication
Application
Priority
- US 0024967 W 20000913
- US 15351199 P 19990913
- US 22438800 P 20000809
Abstract (en)
[origin: WO0119797A2] This invention relates to novel lactams having formula (I) to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of A beta -peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to beta -amyloid production such as Alzheimer's disease and Down's Syndrome.
IPC 1-7
C07D 243/24; A61K 31/55; A61P 43/00; C07D 223/12; C07D 401/04; C07D 409/12; C07D 405/12; C07D 403/12; C07D 401/06
IPC 8 full level
C07D 243/14 (2006.01); A61K 31/55 (2006.01); A61K 31/5513 (2006.01); A61P 25/28 (2006.01); A61P 43/00 (2006.01); C07D 223/12 (2006.01); C07D 223/18 (2006.01); C07D 243/24 (2006.01); C07D 243/26 (2006.01); C07D 401/04 (2006.01); C07D 401/06 (2006.01); C07D 403/04 (2006.01); C07D 405/12 (2006.01); C07D 417/04 (2006.01)
CPC (source: EP)
A61P 25/28 (2017.12); A61P 43/00 (2017.12); C07D 223/18 (2013.01); C07D 243/24 (2013.01); C07D 401/04 (2013.01)
Citation (search report)
See references of WO 0119797A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0119797 A2 20010322; WO 0119797 A3 20020411; AU 7479700 A 20010417; AU 783914 B2 20051222; BR 0014269 A 20020702; CA 2377221 A1 20010322; CN 1399634 A 20030226; EP 1212306 A2 20020612; IL 147774 A0 20020814; JP 2003509411 A 20030311; MX PA02001813 A 20040319
DOCDB simple family (application)
US 0024967 W 20000913; AU 7479700 A 20000913; BR 0014269 A 20000913; CA 2377221 A 20000913; CN 00812784 A 20000913; EP 00963374 A 20000913; IL 14777400 A 20000913; JP 2001523377 A 20000913; MX PA02001813 A 20000913