EP 1212365 A2 20020612 - CRYSTAL STRUCTURES OF DOMAINS OF RECEPTOR PROTEIN TYROSINE KINASES AND THEIR LIGANDS
Title (en)
CRYSTAL STRUCTURES OF DOMAINS OF RECEPTOR PROTEIN TYROSINE KINASES AND THEIR LIGANDS
Title (de)
KRISTALLSTRUKTUREN VON REZEPTOR-TYROSINPROTEINKINASEDOMÄNEN UND IHRE LIGANDE
Title (fr)
STRUCTURES CRISTALLINES DE DOMAINES DE PROTEINES TYROSINE KINASES DE RECEPTEUR ET DE LEURS LIGANDS
Publication
Application
Priority
- US 0023744 W 20000830
- US 15181099 P 19990830
Abstract (en)
[origin: WO0116181A2] The determination and use of three dimensional structures of receptor protein tyrosine kinases and/or their ligands are described. One particular group of such structures includes three dimensional structures of the extracellular domain of RPTKs. The three dimensional structures of RPTKs can faciliate the design and identification of modulators of RPTK function. Other such structures can include of RPTK ligands, such as stem cell factor or a fragment thereof. Modulators of RPTK function can be used to treat diseases that are mediated by inappropriate RPTK activity.
IPC 1-7
C07K 14/71; C12N 9/12; G06F 17/30; C12Q 1/37; A61K 38/00; G01N 33/68
IPC 8 full level
G01N 33/50 (2006.01); C07K 14/71 (2006.01); C12N 9/12 (2006.01); C12Q 1/02 (2006.01); G01N 33/15 (2006.01)
CPC (source: EP)
C07K 14/71 (2013.01); C12N 9/12 (2013.01)
Citation (search report)
See references of WO 0116181A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0116181 A2 20010308; WO 0116181 A3 20020124; AU 7087000 A 20010326; CA 2382812 A1 20010308; EP 1212365 A2 20020612; JP 2003513016 A 20030408
DOCDB simple family (application)
US 0023744 W 20000830; AU 7087000 A 20000830; CA 2382812 A 20000830; EP 00959577 A 20000830; JP 2001520740 A 20000830