EP 1212601 A1 20020612 - GLUCOSE BIOSENSOR
Title (en)
GLUCOSE BIOSENSOR
Title (de)
GLUKOSEBIOSENSOR
Title (fr)
BIOD TECTEUR DE GLUCOSE
Publication
Application
Priority
- US 0023194 W 20000823
- US 15103499 P 19990827
Abstract (en)
[origin: WO0116575A1] A biosensor (10) has a hydrogel (30) in a rigid and preferably biocompatible enclosure (20). The hydrogel (30) includes an immobilized GBM such as concanavalin A (Con A) and an immobilized hexose saccharide such as a-D-mannopyranoside. The immobilized hexose saccharide competitively binds with free glucose to the GBM, thus changing the number of crosslinks in the hydrogel (30), which changes hydrogel swelling tendency and the pressure of the hydrogel in its confined space in proportion to the concentration of free glucose. By measuring the change in hydrogel pressure with a pressure transducer (40), the biosensor (10) is able to accurately measure the concentration of the free glucose molecule without the problem of oxygen limitations and interference encountered by prior art biosensors. A battery (64) powered telemeter (60) operably engaged to the pressure transducer (40) sends a radio data signal to a receiver (66) containing an alarm system operably attached to a computer (62). Furthermore, an alarm system utilizes such a sensor to automatically notify a person that the blood glucose level is outside a predetermined parameter, and/or to automatically inject an agent such as glucose or glycogen which will raise blood glucose levels.
IPC 1-7
G01N 15/06; C12M 1/34; A61K 9/22; G01N 33/53; A61B 5/00; G01N 33/66; G01N 33/487
IPC 8 full level
A61B 5/00 (2006.01); A61K 9/00 (2006.01); A61M 1/36 (2006.01); A61P 3/08 (2006.01); G01N 5/02 (2006.01); G01N 33/483 (2006.01); G01N 33/66 (2006.01)
CPC (source: EP KR)
A61B 5/0031 (2013.01 - EP); A61B 5/1486 (2013.01 - EP); A61P 3/08 (2017.12 - EP); G01N 15/06 (2013.01 - KR); G01N 33/66 (2013.01 - EP)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0116575 A1 20010308; AU 6931500 A 20010326; EP 1212601 A1 20020612; EP 1212601 A4 20060329; JP 2003517588 A 20030527; KR 100771711 B1 20071030; KR 20020035583 A 20020511
DOCDB simple family (application)
US 0023194 W 20000823; AU 6931500 A 20000823; EP 00957741 A 20000823; JP 2001520081 A 20000823; KR 20027002620 A 20020227