EP 1214332 A1 20020619 - CHARGE-MODIFIED NUCLEIC ACID TERMINATORS
Title (en)
CHARGE-MODIFIED NUCLEIC ACID TERMINATORS
Title (de)
LADUNGSMODIFIZIERTE NUKLEINSÄURE-TERMINATOREN
Title (fr)
TERMINATEURS D'ACIDES NUCLEIQUES A CHARGE MODIFIEE
Publication
Application
Priority
- US 0025433 W 20000916
- US 15473999 P 19990917
Abstract (en)
[origin: WO0119841A1] Charge-modified nucleic acid terminators comprising structure (I): Z-X-S-B-L wherein Z is mono-, di- or triphosphate or thiophosphate, or corresponding boranophosphate; X is O, CH2, S, or NH; S is a sugar or a sugar analogue; B is a naturally occuring or a synthetic base; L is alkyl, alkenyl, or alkynyl and is optionally substituted with a reporter moiety; and L, B, S, X, or Z are substituted with a moiety which imparts a net negative charge or a net positive charge to structure (I) at physiological or nucleic acid sequencing conditions. A method of sequencing nucleic acids using the above charge-modified terminators, as well as a method of inhibiting a virus which comprises contacting a cell infected with a virus with a virus-inhibiting amount of the above charge-modified terminator are also disclosed.
IPC 1-7
C07H 19/10; C07H 19/20; C12Q 1/68; G01N 33/53; A61K 31/7052; A61P 31/12
IPC 8 full level
A61P 31/12 (2006.01); C12N 9/12 (2006.01); C12P 19/34 (2006.01); C12Q 1/68 (2006.01); C12Q 1/6869 (2018.01)
CPC (source: EP)
A61P 31/12 (2017.12); C12N 9/1252 (2013.01); C12P 19/34 (2013.01); C12Q 1/6869 (2013.01)
Citation (search report)
See references of WO 0119841A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0119841 A1 20010322; AU 7494100 A 20010417; CA 2382063 A1 20010322; EP 1214332 A1 20020619
DOCDB simple family (application)
US 0025433 W 20000916; AU 7494100 A 20000916; CA 2382063 A 20000916; EP 00963540 A 20000916