EP 1216297 A2 20020626 - DOUBLE TRANSGENIC ANIMALS AS MODELS FOR NEURODEGENERATIVE DISEASE
Title (en)
DOUBLE TRANSGENIC ANIMALS AS MODELS FOR NEURODEGENERATIVE DISEASE
Title (de)
DOPPELTRANSGENE TIERMODELLE FÜR NEURODEGENERATIVE KRANKHEITE
Title (fr)
ANIMAUX TRANSGENIQUES UTILISES COMME MODELES DANS LES MALADIES NEURODEGENERATIVES
Publication
Application
Priority
- EP 0006171 W 20000630
- GB 9915574 A 19990702
- GB 0002674 A 20000204
Abstract (en)
[origin: WO0102552A2] There is provided a nucleic acid vector comprising: (a) a nucleic acid sequence encoding a human Tau protein; (b) a sequence capable of directing expression of said human Tau protein in the nervous system of a non-human animal; and (c) a targeting sequence which facilitates integration of said vector into the genome of said animal so as to prevent expression of equivalent Tau protein or a related or equivalent protein from said animal in favour of said human Tau protein. A further aspect provides a nucleic acid vector comprising: (a) a nucleic acid sequence encoding a human protein capable of modulating human Tau protein; (b) a sequence capable of directing expression of said protein in the nervous system of said animal; and (c) a targeting sequence capable of facilitating integration of said vector into the genome of said animal optionally at a position corresponding to a sequence in said animal encoding an equivalent of said human protein so as to prevent expression of said equivalent sequence in favour of said human protein capable of modulating human Tau protein. The vectors are used to make a transgenic non-human animal by (a) introducing into an embryo cell of said animal one or more of a nucleic acid vector as described above; (b) introducing the embryo from step (a) into a female animal; (c) sustaining the female in step (b) until such time as the embryo has sufficiently developed and is borne from the female; and (d) sustaining the transgenic animal.
[origin: WO0102552A2] There is provided transgenic animals comprising: 1.a nucleic acid vector (a) sequence encoding a human Tau protein; (b) a sequence capable of directing expression of said human Tau protein in the nervous system of a non-human animal; and (c) a targeting sequence which facilitates integration of said vector into the genome of said animal so as to prevent expression of equivalent Tau protein; a nucleic acid vector comprising: (a) a nucleic acid sequence encoding a human protein capable of modulating human Tau protein; (b) a sequence capable of directing expression of said protein in the nervous system of said animal; and (c) a targeting sequence capable of facilitating integration of said vector into the genome of said animal optionally at a position corresponding to a sequence in said animal encoding an equivalent of said human protein.
IPC 1-7
IPC 8 full level
A01K 67/027 (2006.01); A61K 45/00 (2006.01); A61P 21/04 (2006.01); A61P 25/00 (2006.01); A61P 25/16 (2006.01); A61P 25/28 (2006.01); C07K 14/47 (2006.01); C12N 5/10 (2006.01); C12N 9/12 (2006.01); C12N 15/09 (2006.01); C12N 15/85 (2006.01); G01N 33/15 (2006.01); G01N 33/48 (2006.01); G01N 33/50 (2006.01)
CPC (source: EP)
A01K 67/0276 (2013.01); A01K 67/0278 (2013.01); A61P 21/04 (2017.12); A61P 25/00 (2017.12); A61P 25/16 (2017.12); A61P 25/28 (2017.12); C07K 14/4711 (2013.01); C12N 9/1205 (2013.01); C12N 15/8509 (2013.01); A01K 2207/15 (2013.01); A01K 2217/00 (2013.01); A01K 2217/05 (2013.01); A01K 2217/072 (2013.01); A01K 2217/075 (2013.01); A01K 2227/105 (2013.01); A01K 2267/0312 (2013.01); A01K 2267/0318 (2013.01); C12N 2800/30 (2013.01)
Citation (search report)
See references of WO 0102552A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0102552 A2 20010111; WO 0102552 A3 20011220; AU 6267300 A 20010122; AU 782281 B2 20050714; CA 2372742 A1 20010111; EP 1216297 A2 20020626; IL 147406 A0 20020814; JP 2003504015 A 20030204; NO 20020010 D0 20020102; NO 20020010 L 20020102; NZ 515956 A 20040430
DOCDB simple family (application)
EP 0006171 W 20000630; AU 6267300 A 20000630; CA 2372742 A 20000630; EP 00949241 A 20000630; IL 14740600 A 20000630; JP 2001508325 A 20000630; NO 20020010 A 20020102; NZ 51595600 A 20000630