Global Patent Index - EP 1216712 A1

EP 1216712 A1 20020626 - Cyclodextrin-drospirenone inclusion complexes

Title (en)

Cyclodextrin-drospirenone inclusion complexes

Title (de)

Einschlusskomplexe von Drospirenone und Cyclodextrinen

Title (fr)

Complexes d'inclusion de drospirenone et de cyclodextrines

Publication

EP 1216712 A1 20020626 (EN)

Application

EP 00610134 A 20001220

Priority

EP 00610134 A 20001220

Abstract (en)

A clathrate between cyclodextrin (CD) and drospirenone (DRSP) was prepared and used in pharmaceutical compositions. By the method in which the CD-DRSP clathrate was prepared, inclusion complexes between beta - cyclodextrin and DRSP of at least 1:1, 2:1 and 1:2 were made available. As part of an inclusion complex, drospirenone has an increased water solubility, which is advantageous for its use as a medicament for the treatment of menopausal symptoms and for female contraception.

IPC 1-7

A61K 47/48; A61K 31/585

IPC 8 full level

A61K 31/585 (2006.01); A61K 47/48 (2006.01); C08B 37/00 (2006.01)

CPC (source: EP US)

A61K 31/585 (2013.01 - EP US); A61K 47/6951 (2017.07 - EP US); A61P 15/00 (2017.12 - EP); A61P 15/12 (2017.12 - EP); A61P 15/18 (2017.12 - EP); B82Y 5/00 (2013.01 - EP US); C08B 37/0015 (2013.01 - EP US)

Citation (search report)

  • [Y] EP 0398460 A2 19901122 - SCHERING AG [DE]
  • [Y] FR 2515187 A1 19830429 - RICHTER GEDEON VEGYESZET [HU]
  • [Y] WO 9602277 A1 19960201 - SCHERING AG [DE], et al
  • [Y] KRATTENMACHER ROLF: "Drospirenone: Pharmacology and pharmacokinetics of a unique progestogen.", CONTRACEPTION, vol. 62, no. 1, July 2000 (2000-07-01), pages 29 - 38, XP000993492, ISSN: 0010-7824
  • [Y] NORMAN P ET AL: "Drospirenone: Contraceptive, hormone replacement therapy, aldosterone antagonist, progestogen: 1,2-dihydrospirorenone, SH-470, ZK-30595.", DRUGS OF THE FUTURE, vol. 25, no. 12, December 2000 (2000-12-01), pages 1247 - 1256, XP000993474, ISSN: 0377-8282
  • [Y] UEKAMA, K. ET AL: "Inclusion complexations of steroid hormones with cyclodextrins in water and in solid phase", INT. J. PHARM., 1982, VOL. 10, NO. 1, PAGES 1-15, XP000610489
  • [Y] KRALOVA, K. ET AL: "Interactions of beta -cyclodextrin with steroid compounds in aqueous solutions", PHARMAZIE, 1989, VOL. 44, NO. 9, PAGES 623-5, XP000611476
  • [Y] HERMENS W.A.J.J.: "Delivery of hormones: Some new concepts", PHARM. WEEKBL. SCI. ED., 1992, VOL. 14, NO. 4 A, PAGE(S) 253-257, NETHERLANDS, XP002167344
  • [Y] K. UEKAMA: "CYCLODEXTRIN INCLUSION COMPOUNDS: EFFECTS ON STABILITY AND BIO-PHARMACEUTICAL PROPERTIES", TOPICS IN PHARMACEUTICAL SCIENCES, EDS. D.D. BREIMER AND P. SPEISER, 1987, ELSEVIER SCIENCE PUBLISHERS B.V. (BIOMEDICAL DIVISION), PAGES 181-194, XP002167345
  • [Y] UEKAMA K ET AL: "CYCLODEXTRIN DRUG CARRIER SYSTEMS", CHEMICAL REVIEWS,US,AMERICAN CHEMICAL SOCIETY. EASTON, vol. 98, no. 5, 1 July 1998 (1998-07-01), pages 2045 - 2076, XP000771829, ISSN: 0009-2665

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

DOCDB simple family (publication)

EP 1216712 A1 20020626; AR 032204 A1 20031029; AT E543514 T1 20120215; ES 2380653 T3 20120517; PE 20020754 A1 20020823; US 2002128229 A1 20020912; US 2003212043 A1 20031113; US 6610670 B2 20030826

DOCDB simple family (application)

EP 00610134 A 20001220; AR P010105935 A 20011220; AT 01271230 T 20011220; ES 01271230 T 20011220; PE 2001001281 A 20011220; US 2284601 A 20011220; US 46445303 A 20030619