Global Patent Index - EP 1218030 A4

EP 1218030 A4 20040915 - METHODS AND COMPOSITIONS FOR THE TREATMENT AND PREVENTION OF GRAFT REJECTION USING HEAT SHOCK PROTEINS

Title (en)

METHODS AND COMPOSITIONS FOR THE TREATMENT AND PREVENTION OF GRAFT REJECTION USING HEAT SHOCK PROTEINS

Title (de)

METHODEN UND ZUSAMMENSETZUNGEN ZUR BEHANDLUNG UND PRÄVENTION VON TRANSPLANTATABSTOSSUNG DURCH VERWENDUNG VON HITZESCHOCKPROTEINEN

Title (fr)

PROCEDES ET COMPOSITIONS POUR LE TRAITEMENT ET LA PREVENTION DES REJETS DE GREFFES UTILISANT DES PROTEINES DE CHOC THERMIQUE

Publication

EP 1218030 A4 20040915 (EN)

Application

EP 00961701 A 20000908

Priority

  • US 0024711 W 20000908
  • US 39365299 A 19990910

Abstract (en)

[origin: WO0117554A1] Methods for treatment and prevention of graft rejection, e.g., in response to tissue or organ transplantation, are disclosed. The disclosed methods comprise administration of compositions of complexes of heat shock/stress protein (hsps) including, but not limited to, hsp70, hsp90, and gp96, either alone or in combination with each other, noncovalently bound to antigenic molecules, to suppress the immune response to the grafted tissue or organ. In addition, administration of compositions containing un-complexed stress proteins (i.e., free of antigenic molecules) to suppress the immune response to the grafted tissue or organ are also disclosed. The invention encompasses administration of heat shock proteins before, after, or both before and after transplantation or grafting. In addition, the invention encompasses administration of donor tissue sample prior to administration of heat shock protein and subsequent transplantation or grafting.

IPC 1-7

A61K 39/385; A61K 45/00; A01N 37/18; C07K 1/00; C07K 2/00; A61K 39/00

IPC 8 full level

A61K 39/00 (2006.01); A61P 37/06 (2006.01)

CPC (source: EP)

A61K 39/001 (2013.01); A61P 37/06 (2017.12); A61K 2039/6043 (2013.01); A61K 2039/622 (2013.01)

Citation (search report)

  • [X] US 5891653 A 19990406 - ATTFIELD DERRICK CECIL [US]
  • [A] RIZZO MONICA ET AL: "Increased expression of HDJ-2 (heat shock protein 40) and heat shock protein 70 in biopsy specimens of transplanted human lungs", JOURNAL OF HEART AND LUNG TRANSPLANTATION, vol. 17, no. 3, March 1998 (1998-03-01), pages 241 - 249, XP008032559, ISSN: 1053-2498
  • [A] QIAN J ET AL: "Expression of stress proteins and lymphocyte reactivity in heterotopic cardiac allografts undergoing cellular rejection", TRANSPLANT IMMUNOLOGY 1995 UNITED KINGDOM, vol. 3, no. 2, 1995, pages 114 - 123, XP002288908, ISSN: 0966-3274
  • [A] DUQUESNOY R J ET AL: "Evidence for heat shock protein immunity in a rat cardiac allograft model of chronic rejection", TRANSPLANTATION 15 JAN 1999 UNITED STATES, vol. 67, no. 1, 15 January 1999 (1999-01-15), pages 156 - 164, XP008032921, ISSN: 0041-1337
  • See references of WO 0117554A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 0117554 A1 20010315; WO 0117554 A9 20020926; AU 7361900 A 20010410; CA 2383213 A1 20010315; EP 1218030 A1 20020703; EP 1218030 A4 20040915

DOCDB simple family (application)

US 0024711 W 20000908; AU 7361900 A 20000908; CA 2383213 A 20000908; EP 00961701 A 20000908