Global Patent Index - EP 1218032 A4

EP 1218032 A4 20050525 - TREATMENT OF REFRACTORY HUMAN TUMORS WITH EPIDERMAL GROWTH FACTOR RECEPTOR ANTAGONISTS

Title (en)

TREATMENT OF REFRACTORY HUMAN TUMORS WITH EPIDERMAL GROWTH FACTOR RECEPTOR ANTAGONISTS

Title (de)

BEHANDLUNG VON REFRAKTÄREN HUMANEN TUMOREN MIT ANTAGONISTEN DES EPIDERMALEN WACHSTUMSFAKTORREZEPTORS

Title (fr)

TRAITEMENT DE TUMEURS HUMAINES REFRACTAIRES AVEC DES ANTAGONISTES DE RECEPTEURS DU FACTEUR DE CROISSANCE EPIDERMIQUE

Publication

EP 1218032 A4 20050525 (EN)

Application

EP 00928671 A 20000501

Priority

  • US 0011756 W 20000501
  • US 31228499 A 19990514
  • US 37402899 A 19990813

Abstract (en)

[origin: WO0069459A1] A method of inhibiting the growth of refractory tumors that are stimulated by a ligand of epidermal growth factor in human patients, comprising treating the human patients with an effective amount of an epidermal growth factor receptor antagonist.

IPC 1-7

A61K 39/395

IPC 8 full level

A61K 39/395 (2006.01); A61K 45/00 (2006.01); A61K 41/00 (2006.01); A61K 45/06 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01); C07K 16/28 (2006.01)

CPC (source: EP KR US)

A61K 39/395 (2013.01 - KR); A61K 41/0038 (2013.01 - EP US); A61P 35/00 (2018.01 - EP); A61P 43/00 (2018.01 - EP); C07K 16/2863 (2013.01 - EP US); A61K 2039/505 (2013.01 - EP US); C07K 2317/24 (2013.01 - EP US); C07K 2317/622 (2013.01 - EP US)

Citation (search report)

  • [X] WO 9640210 A1 19961219 - IMCLONE SYSTEMS INC [US], et al
  • [X] HUANG S ET AL: "Modulation of radiation in squamous cell carcinomas of the head and neck following EGFR blockade with the anti-EGFR monoclonal antibody C225", PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH ANNUAL MEETING, vol. 40, March 1999 (1999-03-01), & 90TH ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH; PHILADELPHIA, PENNSYLVANIA, USA; APRIL 10-14, 1999, pages 421 - 422, XP002322392, ISSN: 0197-016X
  • [X] PREWETT M ET AL: "Growth inhibition of human pancreatic carcinoma in vitro and in vivo by chimeric anti-EGF receptor monoclonal antibody C225", PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH ANNUAL MEETING, vol. 40, March 1999 (1999-03-01), & 90TH ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH; PHILADELPHIA, PENNSYLVANIA, USA; APRIL 10-14, 1999, pages 730, XP002322393, ISSN: 0197-016X
  • [X] ANDERSON V ET AL: "Dose dependent pharmacokinetics of a chimerized monoclonal antibody (C225) against EGFr", PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH ANNUAL MEETING, vol. 39, March 1998 (1998-03-01), & 89TH ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH; NEW ORLEANS, LOUISIANA, USA; MARCH 28-APRIL 1, 1998, pages 523, XP002322394, ISSN: 0197-016X
  • [X] PREWETT M ET AL: "Growth inhibition of human renal cell carcinoma (RCC) cells in vitro and RCC xenografts in athymic mice by chimeric anti-EGF receptor monoclonal antibody C225", PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH ANNUAL MEETING, vol. 39, March 1998 (1998-03-01), & 89TH ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH; NEW ORLEANS, LOUISIANA, USA; MARCH 28-APRIL 1, 1998, pages 65, XP002322395, ISSN: 0197-016X
  • [X] PANEK ROBERT L ET AL: "In vitro pharmacological characterization of PD 166285, a new nanomolar potent and broadly active protein tyrosine kinase inhibitor", JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 283, no. 3, December 1997 (1997-12-01), pages 1433 - 1444, XP002191995, ISSN: 0022-3565

Citation (examination)

  • BASELGA J. ET AL.: "Phase I studies of anti- Epidermal growth factor receptor chimeric antibody C225 alone or in combination with cisplatin", JOURNAL OF CLINICAL ONCOLOGY, vol. 18, no. 4, February 2000 (2000-02-01), pages 904 - 914, XP009053775
  • PREWETT M, ET AL.: "Mouse-human chimeric anti-epidermal growth factor receptor antibody C225 inhibits the growth of human renal cell carcinoma xenografts in nude mice.", CLINICAL CANCER RESEARCH, vol. 4, no. 12, December 1998 (1998-12-01), pages 2957 - 2966, XP008073033
  • CUNNINGHAM ET AL: "Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan refractory metastatic colorectal cancer", THE NEW ENGLAND JOURNAL OF MEDICINE, vol. 351, 22 July 2004 (2004-07-22), USA, pages 337 - 345, XP008075821
  • VENOOK: "Critical evaluation of current treatments in metastatic colorectal cancer", THE ONCOLOGIST, vol. 10, 2005, pages 250 - 261
  • WILD R. ET AL: "Cetuximabpreclinical antitumor activit (monotherapy and combination based) is not predicted by relative total or activated epidermal growth factor receptor tumor expression levels", MOLECULAR CANCER THERAP, vol. 5, no. 1, January 2006 (2006-01-01), USA, pages 104 - 113
  • CUNNINGHAM D: "Randomised trial of irinotecan plus supportive care versus supportive care alone after fluorouracil failure for patients with metastatic colorectal cancer", THE LANCET, vol. 352, 31 October 1998 (1998-10-31), LONDON, GB, pages 1413 - 1418, XP004265753
  • CIARDIELLO ET AL: "Antitumor activity of sequential treatment with topotecan and anti-epidermal growth factor receptor monoclonal antibody C225", CLINICAL CANCER RESEARCH, vol. 5, no. 4, 1 April 1999 (1999-04-01), pages 909 - 916, XP002516339
  • HOUGHTON ET AL: "Efficacy of topoisomerase I inhibitors, topotecan and irinotecan, administered at low dose levels in protracted schedules to mice bearing xenografts of human tumors", CANCER CHEMOTHERAPY AND PHARMACOLOGY, vol. 36, 1995, pages 393 - 403, XP003021161
  • ROTHENBERG: "A multicenter, phase II trial of weekly irinotecan (CPT-11) in patients with previously treated colorectal carcinoma.", CANCER, vol. 85, 1999, pages 786 - 795, XP003021163
  • PUNT C.: "New drugs in the treatment of colorectal carcinoma", CANCER, vol. 83, no. 4, 15 August 1998 (1998-08-15), pages 679 - 689, XP000882016
  • See also references of WO 0069459A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 0069459 A1 20001123; AU 4687100 A 20001205; AU 782994 B2 20050915; AU 782994 C 20060824; BG 106110 A 20020430; BR 0010524 A 20020528; CA 2373815 A1 20001123; CN 1200734 C 20050511; CN 1361700 A 20020731; CZ 20014083 A3 20020814; EE 200100603 A 20030217; EP 1218032 A1 20020703; EP 1218032 A4 20050525; EP 2042194 A2 20090401; EP 2042194 A3 20090422; HK 1047236 A1 20030214; HU P0201480 A2 20020828; HU P0201480 A3 20090330; IL 146480 A0 20020725; JP 2003520195 A 20030702; JP 2009120583 A 20090604; KR 20020000223 A 20020105; MX PA01011632 A 20021107; NO 20015546 D0 20011113; NO 20015546 L 20020114; PL 365999 A1 20050124; RU 2294761 C2 20070310; SK 16522001 A3 20021008; US 2002012663 A1 20020131; US 2003157104 A1 20030821; US 2005112120 A1 20050526

DOCDB simple family (application)

US 0011756 W 20000501; AU 4687100 A 20000501; BG 10611001 A 20011114; BR 0010524 A 20000501; CA 2373815 A 20000501; CN 00810321 A 20000501; CZ 20014083 A 20000501; EE P200100603 A 20000501; EP 00928671 A 20000501; EP 08015392 A 20000501; HK 02108768 A 20021203; HU P0201480 A 20000501; IL 14648000 A 20000501; JP 2000617919 A 20000501; JP 2008244928 A 20080924; KR 20017014494 A 20011114; MX PA01011632 A 20000501; NO 20015546 A 20011113; PL 36599900 A 20000501; RU 2001130771 A 20000501; SK 16522001 A 20000501; US 1895004 A 20041220; US 84014601 A 20010424; US 99695401 A 20011130