EP 1218319 A1 20020703 - CHEMICAL CONSTRUCTS
Title (en)
CHEMICAL CONSTRUCTS
Title (de)
CHEMISCHE KONSTRUKTIONEN
Title (fr)
CONSTRUCTIONS CHIMIQUES
Publication
Application
Priority
- EP 0009639 W 20001003
- GB 9923577 A 19991005
Abstract (en)
[origin: WO0125171A1] A chemical construct for use in solid phase synthesis comprising a solid support Q having linked thereto via a connecting group Y a substrate R; the connecting group Y having first and second cleavage sites which are orthogonally and selectively cleavable; the second cleavage site being selectively cleavable to release the substrate; and the first cleavage site being located at a position between the second cleavage site and the solid support and being selectively cleavable to release a fragment Fr<u> comprising the substrate and at least a portion of the connecting group Y, wherein the said portion contains a chromophore C<u> which facilitates analysis of the fragment Fr<u> by ultra violet, visible or fluorescence spectroscopy, the chromophore C<u> having a principal log Emax value of at least 2.5 and wherein (i) the principal log Emax value is at least 1.5 times greater than the principal log Emax of the substrate R; or (ii) the chromophore C<u> has an absorption peak at a wavelength remote from absorptions due to the substrate R; and to methods of analysis of products of solid phase synthesis using the constructs.
IPC 1-7
IPC 8 full level
G01N 27/62 (2006.01); C07B 61/00 (2006.01); C07C 311/18 (2006.01); C07C 311/42 (2006.01); C40B 20/04 (2006.01); C40B 30/10 (2006.01); G01N 21/27 (2006.01); G01N 21/33 (2006.01); G01N 21/64 (2006.01); G01N 33/543 (2006.01)
CPC (source: EP)
C07B 61/00 (2013.01); C07C 311/18 (2013.01); C07C 311/42 (2013.01); C40B 20/08 (2013.01); C40B 40/04 (2013.01); C40B 50/14 (2013.01); C40B 70/00 (2013.01); C40B 80/00 (2013.01); G01N 33/54353 (2013.01); C07B 2200/11 (2013.01); G01N 2021/6439 (2013.01)
Citation (search report)
See references of WO 0125171A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0125171 A1 20010412; AU 7661100 A 20010510; EP 1218319 A1 20020703; GB 9923577 D0 19991208; JP 2003511656 A 20030325
DOCDB simple family (application)
EP 0009639 W 20001003; AU 7661100 A 20001003; EP 00966100 A 20001003; GB 9923577 A 19991005; JP 2001528123 A 20001003