EP 1220639 A4 20060607 - APPARATUS FOR MEASURING AN OXYGEN CONCENTRATION GRADIENT AND METHOD OF USE THEREOF
Title (en)
APPARATUS FOR MEASURING AN OXYGEN CONCENTRATION GRADIENT AND METHOD OF USE THEREOF
Title (de)
VORRICHTUNG ZUR MESSUNG EINES SAUERSTOFF-KONZENTRATIONSGRADIENTEN UND VERFAHREN ZUR VERWENDUNG DERSELBEN
Title (fr)
APPAREIL DE MESURE D'UN GRADIENT DE CONCENTRATION EN OXYGENE ET SON PROCEDE D'UTILISATION
Publication
Application
Priority
- US 0041171 W 20001013
- US 15961699 P 19991014
Abstract (en)
[origin: WO0127585A2] The invention provides an improved, reliable and efficient way of measuring the oxygen concentration gradient in a sample by a novel apparatus and accompanying method of calculating linear oxygen concentrations within the sample, permitting diagnostic testing, for example, of the effects of a developmental or metabolic change in a cell or tissue, <i>in vitro</i> or <i>in vivo</i>, in response to disease, injury, radiation, or mechanical or chemical intervention, or simply to changed circumstances, or to measure the oxygen permeability of a membrane or plastic. The apparatus in a preferred embodiment comprises a core digital signal processor (DSP), having sufficient memory (RAM and ROM) to perform the necessary calculations, to control output of excitation light from a light source, and to collect phosphorescent lifetime data; and signal processors (A/D and D/A).
IPC 1-7
IPC 8 full level
A61B 5/00 (2006.01); G01N 21/64 (2006.01)
CPC (source: EP)
A61B 5/14556 (2013.01); G01N 21/6408 (2013.01); G01N 2021/6432 (2013.01)
Citation (search report)
- [XY] WO 9854354 A1 19981203 - UNIV PENNSYLVANIA [US]
- [X] US 5830138 A 19981103 - WILSON DAVID F [US]
- [X] US 5863460 A 19990126 - SLOVACEK RUDOLF E [US], et al
- [XY] US 5518694 A 19960521 - BENTSEN JAMES G [US]
- [Y] US 5281825 A 19940125 - BERNDT KLAUS W [US], et al
- [Y] VINOGRADOV S A ET AL: "PHOSPHORESCENCE QUENCHING AS A METHOD FOR STUDYING OXYGENATION OF HETEROGENEOUS OBJECTS", BIOPHYSICAL JOURNAL, NEW YORK, US, US, vol. 68, no. 2, PART 2, 12 February 1995 (1995-02-12), pages A198, XP001061896, ISSN: 0006-3495
- See references of WO 0127585A2
Citation (examination)
- US 5186173 A 19930216 - ZUCKERMAN RALPH [US]
- DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; April 1998 (1998-04-01), MCILROY B W ET AL: "Spatial measurement of oxygen levels during photodynamic therapy using time-resolved optical spectroscopy", Database accession no. PREV199800321658 & JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B BIOLOGY, vol. 43, no. 1, April 1998 (1998-04-01), pages 47 - 55, ISSN: 1011-1344
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0127585 A2 20010419; WO 0127585 A3 20020103; AU 1964901 A 20010423; AU 766128 B2 20031009; CA 2387492 A1 20010419; CA 2387492 C 20120710; EP 1220639 A2 20020710; EP 1220639 A4 20060607
DOCDB simple family (application)
US 0041171 W 20001013; AU 1964901 A 20001013; CA 2387492 A 20001013; EP 00982645 A 20001013