EP 1220843 A1 20020710 - PYRIDINIUM DERIVATIVES FOR THE TREATMENT OF DIABETIC AND AGING-RELATED VASCULAR COMPLICATIONS
Title (en)
PYRIDINIUM DERIVATIVES FOR THE TREATMENT OF DIABETIC AND AGING-RELATED VASCULAR COMPLICATIONS
Title (de)
PYRIDINIUM-DERIVATE ZUR BEHANDLUNG VON DIABETISCHEN UND ALTERUNGS-RELATIERTEN VASKULÄREN KOMPLIKATIONEN
Title (fr)
DERIVES DE PYRIDINIUM DESTINES AU TRAITEMENT DE COMPLICATIONS VASCULAIRES LIEES AU DIABETE ET AU VIEILLISSEMENT
Publication
Application
Priority
- IB 9901687 W 19991015
- IN 827CA1999 A 19991006
Abstract (en)
[origin: WO0125209A1] The invention discloses compounds of the pyridinium series useful for the management of diabetes and aging-related vascular complications, and particularly in the treatment of complications of diabetes mellitus and other aging-related conditions including kidney disease, nerve damage, atherosclerosis, retinopathy, dermatological conditions and discoloration of teeth by breaking preformed AGE, of general formula (I), or pharmaceutically acceptable salts thereof, wherein, R<1>, R<2> and X are as defined in the specification. The invention also discloses method of preparation of the compounds of the series and pharmaceutical composition having one or more compounds as defined above as active ingredients. The invention further discloses a method of treatment of a diabetic patient by administering the compounds as defined above, either singly or in combination with other drugs for antidiabetic therapy.
IPC 1-7
C07D 213/82; C07D 417/12; C07D 409/06; A61K 31/4427; A61K 31/4425; A61P 37/00; A61P 3/00
IPC 8 full level
A61K 8/00 (2006.01); A61K 8/40 (2006.01); A61K 8/49 (2006.01); A61K 9/08 (2006.01); A61K 31/4425 (2006.01); A61K 47/04 (2006.01); A61K 47/12 (2006.01); C07D 213/80 (2006.01); A61K 47/26 (2006.01); A61K 47/32 (2006.01); A61K 47/34 (2006.01); A61K 47/36 (2006.01); A61P 1/02 (2006.01); A61P 3/00 (2006.01); A61P 3/10 (2006.01); A61P 9/00 (2006.01); A61P 9/10 (2006.01); A61P 13/12 (2006.01); A61P 17/00 (2006.01); A61P 25/00 (2006.01); A61P 27/02 (2006.01); A61P 37/00 (2006.01); A61P 43/00 (2006.01); A61Q 11/00 (2006.01); A61Q 19/08 (2006.01); C07D 213/803 (2006.01); C07D 213/82 (2006.01); C07D 409/06 (2006.01); C07D 417/12 (2006.01)
CPC (source: EP)
A61P 1/02 (2018.01); A61P 3/00 (2018.01); A61P 3/10 (2018.01); A61P 9/00 (2018.01); A61P 9/10 (2018.01); A61P 13/12 (2018.01); A61P 17/00 (2018.01); A61P 25/00 (2018.01); A61P 27/02 (2018.01); A61P 37/00 (2018.01); A61P 43/00 (2018.01); C07D 213/82 (2013.01); C07D 409/06 (2013.01); C07D 417/12 (2013.01)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0125209 A1 20010412; AU 5994499 A 20010510; BR 9915962 A 20030107; CA 2351075 A1 20010412; CN 1329597 A 20020102; CZ 20011808 A3 20010815; EP 1220843 A1 20020710; HK 1044336 A1 20021018; HU P0301687 A2 20030828; JP 2003511370 A 20030325; MX PA02003496 A 20050620; PL 348049 A1 20020506
DOCDB simple family (application)
IB 9901687 W 19991015; AU 5994499 A 19991015; BR 9915962 A 19991015; CA 2351075 A 19991015; CN 99814055 A 19991015; CZ 20011808 A 19991015; EP 99974071 A 19991015; HK 02105890 A 20020812; HU P0301687 A 19991015; JP 2001528155 A 19991015; MX PA02003496 A 19991015; PL 34804999 A 19991015