EP 1221620 A3 20030702 - Method for performing activated clotting time test with reduced sensitivity to the presence of aprotinin and for assessing aprotinin sensitivity
Title (en)
Method for performing activated clotting time test with reduced sensitivity to the presence of aprotinin and for assessing aprotinin sensitivity
Title (de)
Verfahren zum Ausführen einer Bestimmung der "activated clotting time" mit geringer Empfindlichkeit gegenüber die Anwesenheit des Aprotinins sowie zur Ermittlung der Aprotinin-Empfindlichkeit
Title (fr)
Méthode pour effectuer la mesure du "activated clotting time" ayant une sensibilité réduite envers la présence de l'aprotinine ainsi que pour évaluer la sensibilité vis-à-vis de l'aprotinine
Publication
Application
Priority
US 75397401 A 20010103
Abstract (en)
[origin: EP1221620A2] A coagulation test for determining the activated clotting time (ACT) of blood in the presence of heparin that produces test results that are substantially insensitive to the drug aprotinin. The activator is formulated to be a combination of celite and bentonite. The ACT results obtained with this formulation are similar to celite ACT tests on heparinized blood while simultaneously being unaffected by aprotinin. Additionally, a method for quantifying the aprotinin effect of different ACT formulations is disclosed. <IMAGE>
IPC 1-7
IPC 8 full level
G01N 33/48 (2006.01); G01N 33/86 (2006.01)
CPC (source: EP US)
G01N 33/86 (2013.01 - EP US); G01N 2333/8117 (2013.01 - EP US); G01N 2400/40 (2013.01 - EP US)
Citation (search report)
- [A] M.A. DE JONG: "High Dose Thrombin Time Versus the Activated Clotting Time During Cardiopulmonary Bypass", NESECC JOURNAL, vol. 23, no. 2, 1998, pages 10 - 13, XP002221335, Retrieved from the Internet <URL:http://www.nesecc.org/docs/archivearticles/dejong.pdf> [retrieved on 20021118]
- [AD] DIETRICH W ET AL: "INFLUENCE OF HIGH-DOSE APROTININ ON ANTICOAGULATION, HEPARIN REQUIREMENT, AND CELITE- AND KAOLIN-ACTIVATED CLOTTING TIME IN HEPARIN-PRETREATED PATIENTS UNDERGOING OPEN-HEART SURGERY A DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY", ANESTHESIOLOGY, AMERICAN SOCIETY OF ANESTHESIOLOGISTS, PHILADELPHIA, PA,, US, vol. 83, no. 4, October 1995 (1995-10-01), pages 679 - 689, XP002941918, ISSN: 0003-3022
- [T] MESSMETHODEN UND EXPERIMENTELLE AUFBAUTEN, 2003, pages 31, XP002236656, Retrieved from the Internet <URL:darwin.inf.fu-berlin.de/2003/2/Kap3.pdf> [retrieved on 20030331]
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
EP 1221620 A2 20020710; EP 1221620 A3 20030702; JP 2002214238 A 20020731; JP 4010143 B2 20071121; US 2002127730 A1 20020912; US 6632678 B2 20031014
DOCDB simple family (application)
EP 01310782 A 20011221; JP 2001381900 A 20011214; US 75397401 A 20010103