EP 1221951 A4 20040414 - TREATMENT OF PANCREATIC DISEASE
Title (en)
TREATMENT OF PANCREATIC DISEASE
Title (de)
BEHANDLUNG VON PANKREAS-ERKRANKUNGEN
Title (fr)
TRAITEMENT D'UNE MALADIE PANCREATIQUE
Publication
Application
Priority
- AU 0001026 W 20000830
- AU PQ253699 A 19990830
Abstract (en)
[origin: WO0115690A1] The present invention relates to the administration of cyanohydroxybutene (CHB) to eliminate acinar cells in a subject. Subcutaneous injection of CHB at a sub-lethal dosage caused apoptosis of the substantially entire population of acinar cells. The pancreatic lesion has marked early edema with limited inflammatory infiltration, rapid synchronous onset of acinar cell apoptosis and advanced atrophy with a severely limited regenerative response. There is further provided methods of treatment of acinar cell carcinoma and pancreatitis.
IPC 1-7
IPC 8 full level
A61K 31/275 (2006.01); A61P 1/18 (2006.01)
CPC (source: EP)
A61K 31/275 (2013.01); A61P 1/18 (2017.12); A61P 35/00 (2017.12)
Citation (search report)
- [X] KELLY L ET AL: "Massive acinar cell apoptosis with secondary necrosis, origin of ducts in atrophic lobules and failure to regenerate in cyanohydroxybutene pancreatopathy in rats.", INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. ENGLAND AUG 1999, vol. 80, no. 4, August 1999 (1999-08-01), pages 217 - 226, XP002270280, ISSN: 0959-9673
- See references of WO 0115690A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0115690 A1 20010308; AU PQ253699 A0 19990923; CA 2382529 A1 20010308; EP 1221951 A1 20020717; EP 1221951 A4 20040414
DOCDB simple family (application)
AU 0001026 W 20000830; AU PQ253699 A 19990830; CA 2382529 A 20000830; EP 00955960 A 20000830