EP 1222185 A1 20020717 - TETRAHYDROBENZINDOLONE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS 5-HT7 RECEPTOR ANTAGONISTS
Title (en)
TETRAHYDROBENZINDOLONE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS 5-HT7 RECEPTOR ANTAGONISTS
Title (de)
TETRAHYDROBENZINDOLON-DERIVATE, DEREN HERSTELLUNG UND DEREN VERWENDUNG ALS 5-HT7 REZEPTOR ANTAGONISTEN
Title (fr)
DERIVES DE TETRAHYDROBENZYNEDOLONE, LEUR PREPARATION ET LEUR UTILISATION EN TANT QU'ANTAGONISTES DES RECEPTEURS 5-HT 7
Publication
Application
Priority
- EP 0010149 W 20001013
- GB 9924628 A 19991018
- GB 0006168 A 20000314
- GB 0018952 A 20000803
Abstract (en)
[origin: WO0129029A1] The invention relates to compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein R<1> is halogen, C1-6alkyl, hydroxy, C1-6alkoxy, C1-6alkylthio, C1-6alkylsulphinyl, C1-6alkylsulphonyl, amino, mono- or di-C1-6alkylamino, carboxy, carboxamido, hydroxyC1-6alkyl, mono- or di-C1-6alkylaminocarbonyl, sulphonamido, C1-6alkylsulphonylamino, aminoC1-6alkyl, mono- or di-C1-6alkylaminosulphonyl or C1-6alkoxycarbonyl; R<2> is hydrogen, C1-6alkyl or arylC1-6alkyl; p is 0, 1, 2 or 3; R<3> is hydrogen or C1-6alkyl; n is 2, 3, 4, 5 or 6; A is nitrogen, carbon or CH, <o>.....</o>, is a single bond when A is nitrogen or CH or <o>.....</o> is a double bond when A is carbon; X is nitrogen or CH; Y is O, S, NH or N-C1-6alkyl, R<4> is halogen, C1-6alkyl, cyano, CF3, C3-7cycloalkyl, C1-6alkoxy, hydroxy, amino, mono- or di-C1-6alkylamino, acylamino, nitro, C1-6alkoxycarbonyl, C1-6alkylthio, C1-6alkylsulphinyl, C1-6alkylsulphonyl, sulphamoyl, mono- and di-C1-6alkylsulphamoyl, carbamoyl, mono- and di-C1-6alkylcarbamoyl, C1-6alkylsulphonamido, arylsulphonamido, aryl, arylC1-6alkyl, arylC1-6alkoxy, aryloxy and arylthio; m is 0, 1, 2 or 3, having 5-HT7 antagonist activity, processes for their preparation, to compositions containing them and to their use in the treatment of CNS and other disorders.
IPC 1-7
C07D 403/12; C07D 413/12; C07D 417/12; C07D 401/14; A61K 31/445; A61K 31/495; A61K 31/44; A61P 25/00
IPC 8 full level
A61K 31/4439 (2006.01); A61K 31/4535 (2006.01); A61K 31/454 (2006.01); A61K 31/496 (2006.01); A61P 25/00 (2006.01); A61P 25/06 (2006.01); A61P 25/20 (2006.01); A61P 25/22 (2006.01); A61P 25/24 (2006.01); A61P 43/00 (2006.01); C07D 401/14 (2006.01); C07D 403/12 (2006.01); C07D 413/12 (2006.01); C07D 413/14 (2006.01); C07D 417/12 (2006.01); C07D 417/14 (2006.01)
CPC (source: EP)
A61P 25/00 (2017.12); A61P 25/06 (2017.12); A61P 25/20 (2017.12); A61P 25/22 (2017.12); A61P 25/24 (2017.12); A61P 43/00 (2017.12); C07D 401/14 (2013.01); C07D 403/12 (2013.01); C07D 413/12 (2013.01); C07D 417/12 (2013.01)
Citation (search report)
See references of WO 0129029A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0129029 A1 20010426; AU 1025601 A 20010430; EP 1222185 A1 20020717; HK 1049151 A1 20030502; JP 2003512372 A 20030402
DOCDB simple family (application)
EP 0010149 W 20001013; AU 1025601 A 20001013; EP 00971384 A 20001013; HK 02109226 A 20021219; JP 2001531828 A 20001013