Global Patent Index - EP 1222199 A4

EP 1222199 A4 20030312 - N-FORMYL PEPTIDE RECEPTOR COMPLEX WITH A G-PROTEIN KINASE SIGNAL PATHWAY MODIFICATION AGENT

Title (en)

N-FORMYL PEPTIDE RECEPTOR COMPLEX WITH A G-PROTEIN KINASE SIGNAL PATHWAY MODIFICATION AGENT

Title (de)

N-FORMYLPEPTID-REZEPTORKOMPLEX MIT EINER SUBSTANZ, DIE EINEN G-PROTEIN-KINASE-SIGNALÜBERTRAGUNGSWEG MODIFIZIERT

Title (fr)

COMPLEXE DE RECEPTEURS PEPTIDIQUES N-FORMYLE ET D'AGENTS DE MODIFICATION DU MECANISME DE SIGNALISATION DE LA PROTEINE KINASE G

Publication

EP 1222199 A4 20030312 (EN)

Application

EP 00970817 A 20001012

Priority

  • US 0028183 W 20001012
  • US 15967799 P 19991015

Abstract (en)

[origin: WO0129069A1] A method of inhibiting a pro-inflammatory response of a human peripheral blood mononuclear cell or polymorphonuclear cell, or fixed tissue cell is described. The cell is contacted with a pro-inflammatory agent to stimulate a pro-inflammatory response. Then, the cell is contacted with a G protein kinase signal pathway modification agent, thereby inhibiting inflammatory response signal transduction pathways mediated by G protein. A receptor complex is described wherein a G protein kinase signal pathway modification agent binds to a cell surface receptor of a human peripheral blood mononuclear cell or polymorphonuclear cell that has been stimulated by a pro-inflammatory agent.

IPC 1-7

C07K 14/00; G01N 33/53; A61K 38/05; A61K 38/07; C07K 14/72; G01N 33/50; A61P 37/06

IPC 8 full level

A61K 38/05 (2006.01); A61K 38/07 (2006.01); C07K 5/083 (2006.01); C07K 5/103 (2006.01); C07K 14/705 (2006.01); C07K 14/72 (2006.01); G01N 33/50 (2006.01); C12N 5/07 (2010.01); C12N 5/078 (2010.01); C12Q 1/02 (2006.01); G01N 33/15 (2006.01); A61K 38/00 (2006.01)

CPC (source: EP KR)

A61K 38/05 (2013.01 - EP); A61K 38/07 (2013.01 - EP); A61K 38/16 (2013.01 - KR); A61P 37/06 (2018.01 - EP); C07K 5/081 (2013.01 - EP); C07K 5/1013 (2013.01 - EP); C07K 14/723 (2013.01 - EP)

Citation (search report)

  • [X] WO 9925372 A1 19990527 - HISATEK LLC [US]
  • [XY] ALI H ET AL: "Chemoattractant receptor cross-desensitization.", THE JOURNAL OF BIOLOGICAL CHEMISTRY. UNITED STATES 5 MAR 1999, vol. 274, no. 10, 5 March 1999 (1999-03-05), pages 6027 - 6030, XP002226343, ISSN: 0021-9258
  • [XY] DENG X ET AL: "A synthetic peptide derived from human immunodeficiency virus type 1 gp120 downregulates the expression and function of chemokine receptors CCR5 and CXCR4 in monocytes by activating the 7-transmembrane G-protein-coupled receptor FPRL1/LXA4R.", BLOOD. UNITED STATES 15 AUG 1999, vol. 94, no. 4, 15 August 1999 (1999-08-15), pages 1165 - 1173, XP002226344, ISSN: 0006-4971
  • [XY] GRONERT K ET AL: "Identification of a human enterocyte lipoxin A4 receptor that is regulated by interleukin (IL)-13 and interferon gamma and inhibits tumor necrosis factor alpha-induced IL-8 release.", THE JOURNAL OF EXPERIMENTAL MEDICINE. UNITED STATES 20 APR 1998, vol. 187, no. 8, 20 April 1998 (1998-04-20), pages 1285 - 1294, XP002226394, ISSN: 0022-1007
  • [Y] KANAHO Y ET AL: "COMPARISON OF STIMULATION BY CHEMOTACTIC FORMYL PEPTIDE ANALOGS BETWEEN GTPASE ACTIVITY IN NEUTROPHIL PLASMA MEMBRANES AND GRANULE ENZYME RELEASE FROM INTACT NEUTROPHILS", JOURNAL OF LEUKOCYTE BIOLOGY, vol. 47, no. 5, 1990, pages 420 - 428, XP008012138, ISSN: 0741-5400
  • [Y] TORRES M ET AL: "Activation of the mitogen-activated protein kinase pathway by fMet-leu-Phe in the absence of Lyn and tyrosine phosphorylation of SHC in transfected cells.", THE JOURNAL OF BIOLOGICAL CHEMISTRY. UNITED STATES 31 MAY 1996, vol. 271, no. 22, 31 May 1996 (1996-05-31), pages 13244 - 13249, XP002226470, ISSN: 0021-9258
  • See also references of WO 0129069A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 0129069 A1 20010426; AU 8014200 A 20010430; BR 0014742 A 20020827; CA 2387559 A1 20010426; CN 100497374 C 20090610; CN 1633447 A 20050629; CZ 20021342 A3 20030115; EA 200200451 A1 20021031; EP 1222199 A1 20020717; EP 1222199 A4 20030312; HU P0203688 A2 20030228; IL 149125 A0 20021110; JP 2004507441 A 20040311; KR 20020057972 A 20020712; MX PA02003782 A 20021213; NO 20021732 D0 20020412; NO 20021732 L 20020612; PL 356096 A1 20040614; ZA 200202937 B 20030923

DOCDB simple family (application)

US 0028183 W 20001012; AU 8014200 A 20001012; BR 0014742 A 20001012; CA 2387559 A 20001012; CN 00815686 A 20001012; CZ 20021342 A 20001012; EA 200200451 A 20001012; EP 00970817 A 20001012; HU P0203688 A 20001012; IL 14912500 A 20001012; JP 2001531867 A 20001012; KR 20027004714 A 20020412; MX PA02003782 A 20001012; NO 20021732 A 20020412; PL 35609600 A 20001012; ZA 200202937 A 20020415