EP 1222299 A1 20020717 - PRODUCTION OF RECOMBINANT AAV USING ADENOVIRUS COMPRISING AAV REP/CAP GENES
Title (en)
PRODUCTION OF RECOMBINANT AAV USING ADENOVIRUS COMPRISING AAV REP/CAP GENES
Title (de)
HERSTELLUNG REKOMBINANTER AAV MITTELS AAV REP/CAP GENE TRAGENDEN ADENOVIREN
Title (fr)
PRODUCTION DE VIRUS ASSOCIES A L'ADENOVIRUS (AAV) RECOMBINANTS METTANT EN OEUVRE UN ADENOVIRUS COMPRENANT DES GENES REP/CAP ASSOCIES A L'ADENOVIRUS
Publication
Application
Priority
- US 0026948 W 20000929
- US 15746699 P 19991001
Abstract (en)
[origin: WO0125462A1] This invention relates to novel adenoviruses useful in the production of high titers of recombinant adeno-associated virus (rAAV) comprising a foreign DNA insert and methods of making these adenoviruses. The adenovirus comprises the AAV <i>rep</i> gene in which the p5 promoter of <i>rep</i> is replaced by a minimal promoter or by no promoter. The invention also provides methods of producing high levels of rAAV as a substantially homogeneous preparation and compositions of rAAV.
IPC 1-7
IPC 8 full level
C12N 15/09 (2006.01); A61K 35/76 (2006.01); A61K 48/00 (2006.01); C12N 7/00 (2006.01); C12N 15/861 (2006.01); C12N 15/864 (2006.01); A61K 39/00 (2006.01); C12R 1/91 (2006.01)
CPC (source: EP)
C12N 15/86 (2013.01); A61K 48/00 (2013.01); A61K 2039/5256 (2013.01); C12N 2710/10344 (2013.01); C12N 2750/14143 (2013.01); C12N 2830/002 (2013.01); C12N 2830/42 (2013.01); C12N 2830/75 (2013.01); C12N 2840/20 (2013.01); C12N 2840/203 (2013.01)
Citation (search report)
See references of WO 0125462A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0125462 A1 20010412; WO 0125462 A9 20021121; AU 7841400 A 20010510; CA 2385823 A1 20010412; EP 1222299 A1 20020717; JP 2003511037 A 20030325
DOCDB simple family (application)
US 0026948 W 20000929; AU 7841400 A 20000929; CA 2385823 A 20000929; EP 00968512 A 20000929; JP 2001528613 A 20000929