Title (en)

GENE NECESSARY FOR STRIATAL FUNCTION, USES THEREOF, AND COMPOUNDS FOR MODULATING SAME

Title (de)

GEN NOTWENDUNG FÜR STRIATALE FUNKTION, DESSEN VERWENDUNG, UND VERBINDUNGEN ZUR MODULIERUNG DESSELBEN

Title (fr)

GENE NECESSAIRE A LA FONCTION STRIATALE, SES APPLICATIONS ET COMPOSES PERMETTANT DE MODULER CE GENE

Publication

EP 1223937 A2 20020724 (EN)

Application

EP 00967473 A 20001006

Priority

• CA 0001188 W 20001006
• CA 2285690 A 19991007
• US 15804399 P 19991007
• US 21776500 P 20000712

Abstract (en)

[origin: WO0124781A2] PDE10A, a gene that is normally highly expressed in mammalian striatum and elsewhere, has been found to decrease in expression during the development of CAG repeat disorders such as Huntington's disease. The invention teaches a method for detecting the presence of or the predisposition for a CAG repeat disorder. Compounds which modulate CAG repeat disorders and their uses are taught. Methods for screening for further compounds to modulate CAG repeat disorders are also taught.

IPC 1-7

C12N 9/16

IPC 8 full level

A01K 67/027 (2006.01); A61K 31/00 (2006.01); A61K 31/166 (2006.01); A61K 31/4174 (2006.01); A61K 31/437 (2006.01); A61K 31/4985 (2006.01); A61K 31/513 (2006.01); A61K 31/519 (2006.01); A61K 31/65 (2006.01); A61K 45/00 (2006.01); A61P 25/00 (2006.01); C12N 15/09 (2006.01); C12Q 1/02 (2006.01); C12Q 1/68 (2006.01); G01N 33/15 (2006.01); G01N 33/50 (2006.01)

CPC (source: EP)

A61K 31/00 (2013.01); A61K 31/4985 (2013.01); A61K 31/65 (2013.01); A61P 25/00 (2017.12); A61P 25/14 (2017.12); C12Q 1/6883 (2013.01); C12Q 2600/158 (2013.01)

Citation (search report)

See references of WO 0124781A2

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 0124781 A2 20010412; WO 0124781 A3 20020207; AU 7766300 A 20010510; EP 1223937 A2 20020724; JP 2003510349 A 20030318

DOCDB simple family (application)

CA 0001188 W 20001006; AU 7766300 A 20001006; EP 00967473 A 20001006; JP 2001527780 A 20001006