EP 1223949 A1 20020724 - EXTENDED RELEASE FORMULATIONS OF ERYTHROMYCIN DERIVATIVES
Title (en)
EXTENDED RELEASE FORMULATIONS OF ERYTHROMYCIN DERIVATIVES
Title (de)
FORMULIERUNGEN VON ERYTHROMYCINDERIVATEN MIT VERLÄNGERTER FREIGABE
Title (fr)
FORMULATIONS DE DERIVES D'ERYTHROMYCINE A LIBERATION PROLONGEE
Publication
Application
Priority
- US 0028407 W 20001013
- US 41691699 A 19991013
Abstract (en)
[origin: WO0126663A1] Disclosed is a pharmaceutical composition for extended release of an erythromycin derivative in the gastrointestinal environment. The composition comprises an erythromycin derivative and a pharmaceutically acceptable polymer so that, when ingested orally, the composition induces statistically significantly lower Cmax in the plasma than an immediate release composition of the erythromycin derivative while maintaining bioavailability and minimum concentration substantially equivalent to that of the immediate release composition of the erythromycin derivative upon multiple dosing. The compositions of the invention have an improved taste profile and reduced gastrointestinal side effects as compared to those for the immediate release composition.
IPC 1-7
IPC 8 full level
A61K 9/20 (2006.01); A61K 9/22 (2006.01); A61K 9/36 (2006.01); A61K 31/7048 (2006.01); A61K 47/30 (2006.01); A61P 31/04 (2006.01)
CPC (source: EP KR US)
A61K 9/2054 (2013.01 - EP US); A61K 9/28 (2013.01 - EP US); A61K 31/7048 (2013.01 - EP KR US); A61P 31/00 (2018.01 - EP); A61P 31/04 (2018.01 - EP); A61K 9/2018 (2013.01 - EP US)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0126663 A1 20010419; AR 026045 A1 20021226; AU 1203601 A 20010423; BG 106683 A 20021229; BR 0010485 A 20020820; CA 2387621 A1 20010419; EP 1223949 A1 20020724; HU P0203540 A2 20030228; HU P0203540 A3 20030328; IL 149033 A0 20021110; KR 20020068522 A 20020827; NO 20021747 D0 20020412; PL 354783 A1 20040223; SK 4862002 A3 20021008; US 2003133981 A1 20030717; US 2006039969 A1 20060223; US 6551616 B1 20030422; US 6872407 B2 20050329
DOCDB simple family (application)
US 0028407 W 20001013; AR P000105406 A 20001013; AU 1203601 A 20001013; BG 10668302 A 20020509; BR 0010485 A 20001013; CA 2387621 A 20001013; EP 00973534 A 20001013; HU P0203540 A 20001013; IL 14903300 A 20001013; KR 20027004725 A 20020412; NO 20021747 A 20020412; PL 35478300 A 20001013; SK 4862002 A 20001013; US 30216602 A 20021122; US 41691699 A 19991013; US 9163705 A 20050328