EP 1223958 A2 20020724 - METHODS OF PREPARATION AND COMPOSITION OF PEPTIDE CONSTRUCTS USEFUL FOR TREATMENT OF AUTOIMMUNE AND TRANSPLANT RELATED HOST VERSUS GRAFT CONDITIONS
Title (en)
METHODS OF PREPARATION AND COMPOSITION OF PEPTIDE CONSTRUCTS USEFUL FOR TREATMENT OF AUTOIMMUNE AND TRANSPLANT RELATED HOST VERSUS GRAFT CONDITIONS
Title (de)
PRÄPARATIONSMETHODEN UND VERBINDUNGEN VON PEPTIDKONSTRUKTIONEN DIE SICH ZUR BEHANDLUNG VON AUTOIMMUN- BZW. TRANSPLANTATIONSBEDINGTEN "HOST VERSUS GRAFT" PATHOGENESEN EIGNEN
Title (fr)
METHODES DE PREPARATION ET COMPOSITION DE CONSTRUCTIONS PEPTIDIQUES UTILES DANS LE TRAITEMENT D'ETATS AUTO-IMMUNES ET DE GREFFES LIEES A LA REACTION DU GREFFON CONTRE L'HOTE
Publication
Application
Priority
- US 0041646 W 20001027
- US 16173499 P 19991027
Abstract (en)
[origin: WO0136448A2] Peptide constructs including a first peptide segment which includes an amino acid sequence associated with autoimmune disease, asthma, allergy or xeno- or allograft transplantation rejections bonded directly or via a linker or spacer to a second peptide which binds to T cells and which will redirect the immune response from a harmful Th1 response to a less harmful Th2 response, or which will bind to T cells to initiate, but not complete, an immune response causing the T cells to which the first peptide binds, to undergo anergy and apoptosis, are useful in treating autoimmune conditions. For instance, the peptide construct NGQEEKAGVVSTGLIGGGDSAFDVLSFTAEEKAGVYK (SEQ ID NO:14) wherein Th2 stimulating Peptide G (SEQ ID NO:15) is covalently linked, via spacer GGG, to cardiac myosin molecule My1 (SEQ ID NO:16), can be used for treatment or prevention of myocarditis.
IPC 1-7
IPC 8 full level
A61K 38/00 (2006.01); A61P 11/06 (2006.01); A61P 37/02 (2006.01); A61P 37/08 (2006.01); C07K 14/00 (2006.01); C07K 14/78 (2006.01); C07K 19/00 (2006.01)
CPC (source: EP)
A61P 11/06 (2017.12); A61P 37/02 (2017.12); A61P 37/08 (2017.12); C07K 14/4713 (2013.01); C07K 14/78 (2013.01); A61K 38/00 (2013.01)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0136448 A2 20010525; WO 0136448 A3 20020207; WO 0136448 A8 20020620; AU 4134901 A 20010530; EP 1223958 A2 20020724; EP 1223958 A4 20040721; EP 1964854 A2 20080903; JP 2003514828 A 20030422
DOCDB simple family (application)
US 0041646 W 20001027; AU 4134901 A 20001027; EP 00992133 A 20001027; EP 08156124 A 20001027; JP 2001538937 A 20001027