EP 1224169 A2 20020724 - PRODUCTION OF 5-SUBSTITUTED INDOLINONES AND USE THEREOF AS MEDICAMENTS
Title (en)
PRODUCTION OF 5-SUBSTITUTED INDOLINONES AND USE THEREOF AS MEDICAMENTS
Title (de)
IN 5-STELLUNG SUBSTITUIERTE INDOLINONE UND IHRE VERWENDUNG ALS KINASE UND CYCLIN/CDK-KOMPLEXE INHIBITOREN
Title (fr)
INDOLINONES SUBSTITUEES EN POSITION 5, LEUR PRODUCTION ET LEUR UTILISATION COMME MEDICAMENT
Publication
Application
Priority
- DE 19949209 A 19991013
- EP 0009847 W 20001007
Abstract (en)
[origin: DE19949209A1] The invention relates to 5-substituted indolinones of general formula (I), where R<1> to R<5> and X are as defined in claim 1, the isomers and salts thereof, in particular, the physiologically acceptable salts, which exhibit valuable pharmacological properties. Said properties, in particular, include an inhibitory effect on various kinases and cyclin/CDK complexes, receptor thyrosine kinases and on the proliferation of tumour cells. The invention further relates to medicaments containing these compounds, use and methods for production thereof.
IPC 1-7
C07D 209/34; A61K 31/404; A61P 43/00; C07D 401/12; C07F 9/572
IPC 8 full level
C07D 209/34 (2006.01); C07D 401/12 (2006.01); C07D 403/12 (2006.01); C07D 417/12 (2006.01); C07F 9/572 (2006.01)
CPC (source: EP)
A61P 35/00 (2017.12); A61P 43/00 (2017.12); C07D 209/34 (2013.01); C07D 401/12 (2013.01); C07D 403/12 (2013.01); C07D 417/12 (2013.01); C07F 9/5728 (2013.01)
Citation (search report)
See references of WO 0127080A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
DE 19949209 A1 20010419; AR 026037 A1 20021226; AU 7663100 A 20010423; CO 5261507 A1 20030331; EP 1224169 A2 20020724; WO 0127080 A2 20010419; WO 0127080 A3 20011122
DOCDB simple family (application)
DE 19949209 A 19991013; AR P000105395 A 20001013; AU 7663100 A 20001007; CO 00077919 A 20001012; EP 0009847 W 20001007; EP 00966136 A 20001007