EP 1224193 A1 20020724 - PROCESS FOR THE PREPARATION OF PHOSPHOROTHIOATE TRIESTERS AND OLIGONUCLEOTIDES
Title (en)
PROCESS FOR THE PREPARATION OF PHOSPHOROTHIOATE TRIESTERS AND OLIGONUCLEOTIDES
Title (de)
VERFAHREN ZUR HERSTELLUNG VON PHOSPHOROTHIOAT-TRIESTERN UND OLIGONUKLEOTIDEN
Title (fr)
PREPARATION DE PHOSPHOROTHIOATE TRIESTERS ET D'OLIGONUCLEOTIDES
Publication
Application
Priority
- GB 0003912 W 20001012
- GB 9924285 A 19991014
Abstract (en)
[origin: WO0127126A1] A process for the synthesis of a phosphorothioate triester is provided. The process comprises the reaction, in the presence of a coupling agent, of an H-phosphonate with a substrate comprising a free hydroxy group and bonded to a solid support, thereby forming a supported H-phosphonate diester, and subjecting the H-phosphonate diester to sulphur transfer with a sulphur transfer agent.
IPC 1-7
IPC 8 full level
C07H 21/02 (2006.01); C07H 1/00 (2006.01); C07H 21/00 (2006.01); C07H 21/04 (2006.01)
CPC (source: EP)
C07H 1/00 (2013.01); C07H 21/00 (2013.01)
Citation (search report)
See references of WO 0127126A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0127126 A1 20010419; AU 7803500 A 20010423; CA 2386867 A1 20010419; CN 1409719 A 20030409; EP 1224193 A1 20020724; GB 9924285 D0 19991215; JP 2003517467 A 20030527
DOCDB simple family (application)
GB 0003912 W 20001012; AU 7803500 A 20001012; CA 2386867 A 20001012; CN 00816977 A 20001012; EP 00968075 A 20001012; GB 9924285 A 19991014; JP 2001530344 A 20001012