Global Patent Index - EP 1224265 A4

EP 1224265 A4 20041124 - NOVEL HUMAN POTASSIUM CHANNEL SUBUNIT

Title (en)

NOVEL HUMAN POTASSIUM CHANNEL SUBUNIT

Title (de)

NEUE UNTEREINHEIT EINES HUMANEN KALIUMKANALS

Title (fr)

NOUVELLE SOUS UNITE DE CANAL POTASSIQUE HUMAIN

Publication

EP 1224265 A4 20041124 (EN)

Application

EP 00968933 A 20001010

Priority

  • US 0028014 W 20001010
  • US 15878199 P 19991012

Abstract (en)

[origin: WO0127246A1] The present invention is directed to novel human DNA sequences encoding IsK2, a potassium channel subunit, the protein encoded by the DNA sequences, vectors comprising the DNA sequences, host cells containing the vectors, and methods of identifying inhibitors and agonists of potassium channels containing the human IsK2 subunit.

IPC 1-7

C12N 5/10; C12N 15/12; C12N 15/63; C12N 15/64; C07K 14/705; C07K 14/71; C07K 16/18; G01N 33/53; G01N 33/567

IPC 8 full level

G01N 33/50 (2006.01); C07K 14/47 (2006.01); C07K 14/705 (2006.01); C07K 16/18 (2006.01); C12N 1/15 (2006.01); C12N 1/19 (2006.01); C12N 1/21 (2006.01); C12N 5/10 (2006.01); C12N 15/09 (2006.01); C12N 15/12 (2006.01); C12Q 1/02 (2006.01); C12Q 1/68 (2006.01); G01N 33/15 (2006.01); G01N 33/566 (2006.01); G01N 33/68 (2006.01)

CPC (source: EP)

C07K 14/705 (2013.01); G01N 33/6872 (2013.01)

Citation (search report)

  • [T] WO 0063434 A1 20001026 - UNIV UTAH RES FOUND [US], et al
  • [T] WO 0222875 A2 20020321 - UNIV YALE [US], et al
  • [X] DATABASE GENEBANK 29 April 1999 (1999-04-29), ABBOTT, G.W.ET AL.: "Homo sapiens minK-related peptide 1 mRNA, complete cds", XP002297392, retrieved from GENEBANK Database accession no. AF071002 & DATABASE UNIPROT 30 May 2000 (2000-05-30), "Potassium voltage-gated channel subfamily E member 2 (Minimum potassium ion channel-related peptide 1) (Potassium channel beta subunit MiRP1) (MinK-related peptide 1)", XP002297395, retrieved from UNIPROT Database accession no. Q9Y6J6
  • [X] DATABASE GENEBANK 29 April 1999 (1999-04-29), ABBOTT, G.W. ET AL.: "Rattus norvegicus minK-related peptide 1 mRNA, complete cds", XP002297393, retrieved from GENEBANK Database accession no. AF071003 & DATABASE UNIPROT 30 May 2000 (2000-05-30), "Potassium voltage-gated channel subfamily E member 2 (Minimum potassium ion channel-related peptide 1) (Potassium channel beta subunit MiRP1) (MinK-related peptide 1)", XP002297396, retrieved from UNIPROT Database accession no. Q9WTW0
  • [X] DATABASE GENEBANK 13 May 1998 (1998-05-13), "Homo sapiens genomic DNA, chromosome 21q22.1, segment 23/28, complete sequence", XP002297394, retrieved from GENEBANK Database accession no. AP000052
  • [PX] TINEL NORBERT ET AL: "KCNE2 confers background current characteristics to the cardiac KCNQ1 potassium channel", EMBO (EUROPEAN MOLECULAR BIOLOGY ORGANIZATION) JOURNAL, vol. 19, no. 23, 1 December 2000 (2000-12-01), pages 6326 - 6330, XP002297388, ISSN: 0261-4189
  • [PX] TINEL N ET AL: "M-type KCNQ2-KCNQ3 potassium channels are modulated by the KCNE2 subunit", FEBS LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 480, no. 2-3, 1 September 2000 (2000-09-01), pages 137 - 141, XP004337508, ISSN: 0014-5793
  • [T] ABBOTT GEOFFREY W ET AL: "Disease-associated mutations in KCNE potassium channel subunits (MiRPs) reveal promiscuous disruption of multiple currents and conservation of mechanism", FASEB JOURNAL, vol. 16, no. 3, March 2002 (2002-03-01), pages 390 - 400, XP002297389, ISSN: 0892-6638
  • [T] ISBRANDT DIRK ET AL: "Identification and functional characterization of a novel KCNE2 (MiRP1) mutation that alters HERG channel kinetics", JOURNAL OF MOLECULAR MEDICINE (BERLIN), vol. 80, no. 8, August 2002 (2002-08-01), pages 524 - 532, XP002297390, ISSN: 0946-2716
  • [T] YU H ET AL: "MinK-related peptide 1: A beta subunit for the HCN ion channel subunit family enhances expression and speeds activation.", CIRCULATION RESEARCH. 22 JUN 2001, vol. 88, no. 12, 22 June 2001 (2001-06-22), pages E84 - E87, XP002297391, ISSN: 1524-4571
  • See references of WO 0127246A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 0127246 A1 20010419; CA 2387237 A1 20010419; EP 1224265 A1 20020724; EP 1224265 A4 20041124; JP 2003511065 A 20030325

DOCDB simple family (application)

US 0028014 W 20001010; CA 2387237 A 20001010; EP 00968933 A 20001010; JP 2001530451 A 20001010