EP 1225955 A1 20020731 - ARYL OLEFINIC AZACYCLIC, AND ARYL ACETYLENIC AZACYCLIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS INHIBITORS OF NICOTINIC CHOLINERGIC RECEPTORS
Title (en)
ARYL OLEFINIC AZACYCLIC, AND ARYL ACETYLENIC AZACYCLIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS INHIBITORS OF NICOTINIC CHOLINERGIC RECEPTORS
Title (de)
ARYL-OLEFINISCHE-AZACYCLISCHE, UND ARYL-ACETYLEN-AZACYCLISCHE VERBINDUNGEN, DIESE ENTHALTENDE PHARMAZEUTISCHE ZUBEREITUNGEN UND IHRE VERWENDUNG ALS INHIBITOREN VON NIKOTIN CHOLINERGEN REZEPTOREN
Title (fr)
COMPOSES AZACYCLIQUES OLEFINIQUES D'ARYLE, COMPOSES AZACYCLIQUES ACETYLENIQUES D'ARYLE, COMPOSITIONS PHARMACEUTIQUES LES CONTENANT ET LEUR UTILISATION EN TANT QU'INHIBITEURS DE RECEPTEURS CHOLINERGIQUES NICOTINIQUES
Publication
Application
Priority
- US 0018292 W 20000630
- US 43170099 A 19991101
Abstract (en)
[origin: WO0132264A1] Patients susceptible to or suffering from conditions and disorders, such as central nervous system disorders, are treated by administering to a patient in need thereof aryl olefinic azacyclic compounds and aryl acetylenic azacylic compounds, including pyridyl olefinic cycloalkylamines and pyridyl acetylenic cycloalkylamines. Exemplary compounds include (S)-(E)-3-(3-pyrrolidin-2-yl-prop-1-enyl)pyridine, (S)-(E)-3-(2-pyrrolidin-2-ylvinyl)pyridine, 3-(2-pyrrolidin-2-ylethenyl)pyridine, 3-(3-pyrrolidin-2-ylprop-1-enyl)pyridine, 3-(2-(2-azetidinyl)ethenyl)pyridine, 3-(3-(2-azetidinyl) prop-1-enyl)pyridine, 2-(2-(3-pyridyl)ethenyl)-1-azabicyclo[3.3.0]octane, 2-(3-(3-pyridyl)prop-2-enyl)-1-azabicyclo[3.3.0]octane, 3-(2-(3-pyridyl)ethenyl)-2-azabicyclo[2.2.1]heptane, 3-(3-(3-pyridyl)prop-2-enyl)-2-azabicyclo[2.2.1]heptane, 2-(2-(3-pyridyl)ethenyl)-7-azabicyclo[2.2.1]heptane, 2-(3-(3-pyridyl)prop-2-enyl)-7-azabicyclo[2.2.1]heptane, 2-(2-(3-pyridyl)ethenyl)quinuclidine and 2-(3-(3-pyridyl)prop-2-enyl)quinuclidine.
IPC 1-7
A61P 25/00; A61K 31/4406; C07D 453/02; C07D 213/32; C07D 401/06; C07D 487/04; C07D 209/02
IPC 8 full level
A61K 31/407 (2006.01); A61K 31/44 (2006.01); A61K 31/4427 (2006.01); A61K 31/4439 (2006.01); A61K 31/505 (2006.01); A61P 1/04 (2006.01); A61P 25/00 (2006.01); A61P 25/04 (2006.01); A61P 25/08 (2006.01); A61P 25/14 (2006.01); A61P 25/16 (2006.01); A61P 25/22 (2006.01); A61P 25/28 (2006.01); C07D 209/02 (2006.01); C07D 213/32 (2006.01); C07D 401/06 (2006.01); C07D 401/14 (2006.01); C07D 453/02 (2006.01); C07D 487/04 (2006.01)
CPC (source: EP)
A61K 31/44 (2013.01); A61K 31/505 (2013.01); A61P 1/04 (2017.12); A61P 25/00 (2017.12); A61P 25/04 (2017.12); A61P 25/08 (2017.12); A61P 25/14 (2017.12); A61P 25/16 (2017.12); A61P 25/22 (2017.12); A61P 25/28 (2017.12); C07D 209/02 (2013.01); C07D 213/32 (2013.01); C07D 401/06 (2013.01); C07D 401/14 (2013.01); C07D 453/02 (2013.01); C07D 487/04 (2013.01)
Citation (search report)
See references of WO 0132264A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0132264 A1 20010510; AU 6204500 A 20010514; AU 780492 B2 20050324; CA 2389645 A1 20010510; EP 1225955 A1 20020731; JP 2003513054 A 20030408
DOCDB simple family (application)
US 0018292 W 20000630; AU 6204500 A 20000630; CA 2389645 A 20000630; EP 00948568 A 20000630; JP 2001534467 A 20000630