EP 1226167 A1 20020731 - MODIFIED PEPTIDES AND PEPTIDOMIMETICS FOR USE IN IMMUNOTHERAPY
Title (en)
MODIFIED PEPTIDES AND PEPTIDOMIMETICS FOR USE IN IMMUNOTHERAPY
Title (de)
MODIFIZIERTE PEPTIDE UND PEPTIDOMIMETIKA ZUR VERWENDUNG IN DER IMMUNOTHERAPIE
Title (fr)
PEPTIDES ET PEPTIDOMIMETIQUES MODIFIES DESTINES A L'IMMUNOTHERAPIE
Publication
Application
Priority
- EP 00972790 A 20001012
- EP 0010230 W 20001012
- EP 99203427 A 19991018
Abstract (en)
[origin: WO0129081A1] The invention relates to a modified peptide derived from H-Arg-Ser-Phe-Thr-Leu-Ala-Ser-Ser-Glu-Thr-Gly-Val-Gly-OH having general formula (II): Q-A1-A2-A3-A4-A5-A6-A7-A8-A9-A10-A11-A12-A13-Z. In general formula (II), A1 through A13 correspond with the amino acids of formula (I), Q corresponds with H and Z corresponds with OH. The modifications according to the present invention are selected one or more of the groups a, b or c, consisting of a) substitution of 1-6, preferably 1-4 amino acids at A1 through A13 with non-natural amino acids or beta amino acids; b) substitution of one or more amide bonds with reduced amide bonds or ethylene isosteres; c) substitutions at Q and/or Z and, optionally, d) substitution of natural amino acids up to a total of 6 modifications. The peptides can be used for inducing tolerance induction in patients suffering from autoimmune diseases.
IPC 1-7
IPC 8 full level
A61K 38/10 (2006.01); A61K 39/00 (2006.01); A61P 19/02 (2006.01); A61K 38/00 (2006.01); A61P 37/06 (2006.01); C07K 7/00 (2006.01); C07K 14/47 (2006.01); G01N 33/68 (2006.01); A61K 38/095 (2019.01)
CPC (source: EP KR)
A61K 39/0008 (2013.01 - EP); A61P 19/02 (2018.01 - EP); A61P 37/00 (2018.01 - EP); A61P 37/06 (2018.01 - EP); C07K 14/47 (2013.01 - KR); C07K 14/4713 (2013.01 - EP); A61K 38/00 (2013.01 - EP)
Citation (examination)
- STEMMER ET AL: "Protection against lymphocytic choriomeningitis viurs infection induced by a reduced peptide bond analogue of the H-2Db-restricted CD8+ T cell epitope GP33", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 274, no. 9, 26 February 1999 (1999-02-26), pages 5550 - 5556
- BENKIRANE ET AL: "Exploration of requirements for peptidomimetic immune recognition.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 271, no. 52, 27 December 1996 (1996-12-27), pages 33218 - 33224
- See also references of WO 0129081A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0129081 A1 20010426; AR 026068 A1 20021226; AU 1139601 A 20010430; AU 780238 B2 20050310; BR 0014803 A 20020611; CA 2386398 A1 20010426; CN 1379786 A 20021113; CO 5271650 A1 20030430; CZ 20021356 A3 20020717; EP 1226167 A1 20020731; HK 1046693 A1 20030124; HU P0203504 A2 20030428; HU P0203504 A3 20050329; IL 148778 A0 20020912; JP 2003512388 A 20030402; KR 20020047245 A 20020621; MX PA02003520 A 20020820; NO 20021763 D0 20020415; NO 20021763 L 20020415; NZ 518256 A 20040130; PE 20010692 A1 20010706; PL 354590 A1 20040126; RU 2002113107 A 20040110; SK 6842002 A3 20020910; TR 200201036 T2 20020821; ZA 200202577 B 20030923
DOCDB simple family (application)
EP 0010230 W 20001012; AR P000105458 A 20001018; AU 1139601 A 20001012; BR 0014803 A 20001012; CA 2386398 A 20001012; CN 00814418 A 20001012; CO 00079334 A 20001018; CZ 20021356 A 20001012; EP 00972790 A 20001012; HK 02108208 A 20021113; HU P0203504 A 20001012; IL 14877800 A 20001012; JP 2001531879 A 20001012; KR 20027004940 A 20020418; MX PA02003520 A 20001012; NO 20021763 A 20020415; NZ 51825600 A 20001012; PE 0011072000 A 20001017; PL 35459000 A 20001012; RU 2002113107 A 20001012; SK 6842002 A 20001012; TR 200201036 T 20001012; ZA 200202577 A 20020402